INT17673

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Context Info
Confidence 0.09
First Reported 1981
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.63
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lnpep) plasma membrane (Lnpep) intracellular (Lnpep)
cytoplasm (Lnpep)
Anatomy Link Frequency
tail 2
SCN 2
Lnpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 24 100.00 Very High Very High Very High
cva 12 100.00 Very High Very High Very High
Opioid 13 99.84 Very High Very High Very High
Endogenous opioid 6 99.70 Very High Very High Very High
tetrodotoxin 7 99.68 Very High Very High Very High
Inflammation 1 97.76 Very High Very High Very High
antagonist 4 87.28 High High
opiate 4 86.48 High High
Chronic pancreatitis 1 81.52 Quite High
dexamethasone 8 80.40 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 6 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 12 99.48 Very High Very High Very High
Disorders Of Creatine Metabolism 3 99.44 Very High Very High Very High
Pancreatitis 4 99.08 Very High Very High Very High
INFLAMMATION 1 97.76 Very High Very High Very High
Hypertension 8 95.40 Very High Very High Very High
Pancreatic Cancer 4 90.48 High High
Cv Unclassified Under Development 3 89.56 High High
Shock 2 54.24 Quite High
Sprains And Strains 2 47.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VP release from SCN explants was consistently attenuated during TTX treatment, with the amplitude of this effect depending on the time of administration.
Negative_regulation (attenuated) of Localization (release) of VP in SCN associated with tetrodotoxin
1) Confidence 0.09 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1933388 Disease Relevance 0 Pain Relevance 0.51
Overhydration inhibits release of vasopressin (VP) and oxytocin (OT) from the hypothalamo-neurohypophysial system during hypovolemia.
Negative_regulation (inhibits) of Localization (release) of VP associated with pressure volume 2 under development
2) Confidence 0.09 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3605388 Disease Relevance 0.25 Pain Relevance 0.21
The neuromodulatory role of opioid peptides in the release of neurohypophysial hormones appears to be altered in the SHR such that VP release is suppressed and OT release is augmented.
Negative_regulation (suppressed) of Localization (release) of VP associated with opioid
3) Confidence 0.09 Published 1985 Journal Brain Res. Section Abstract Doc Link 3978414 Disease Relevance 0.23 Pain Relevance 0.44
Inhibition of VP and OT release by water in hypovolemia is independent of opioid peptides.
Negative_regulation (Inhibition) of Localization (release) of VP associated with pressure volume 2 under development, cva and opioid
4) Confidence 0.08 Published 1987 Journal Am. J. Physiol. Section Title Doc Link 3605388 Disease Relevance 0.39 Pain Relevance 0.42
Thus, regardless of the hydrational state of the animal, opioid peptides inhibited release of OT but not VP during hemorrhage.
Negative_regulation (inhibited) of Localization (release) of VP associated with cva and opioid
5) Confidence 0.08 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3605388 Disease Relevance 0.42 Pain Relevance 0.48
In conclusion, endogenous opioid peptides tonically inhibit OT release in WKY rats, whereas VP release is decreased by opioid peptides in SHRs, 16-17 weeks of age.
Negative_regulation (decreased) of Localization (release) of VP associated with endogenous opioid and opioid
6) Confidence 0.07 Published 1985 Journal Brain Res. Section Abstract Doc Link 3978414 Disease Relevance 0.25 Pain Relevance 0.49
The origin of endogenous opioid peptides that inhibit release of vasopressin (VP) and oxytocin (OT) into the bloodstream after tail electroshock was investigated.
Negative_regulation (inhibit) of Localization (release) of VP in tail associated with endogenous opioid
7) Confidence 0.06 Published 1985 Journal Brain Res. Bull. Section Abstract Doc Link 4084815 Disease Relevance 0.05 Pain Relevance 0.44
Science renal enzyme excretion (alpha-glucosidase, gamma-glutamyltranspeptidase, leucine aminopeptidase) was not found to be invariably elevated when trypsin/creatinine clearance ratio was increased, tubular damage cannot be assumed as constituting the only reason for an altered clearance ratio.
Negative_regulation (elevated) of Localization (excretion) of leucine aminopeptidase associated with disorders of creatine metabolism
8) Confidence 0.01 Published 1981 Journal Gastroenterology Section Abstract Doc Link 6165644 Disease Relevance 1.02 Pain Relevance 0.13

General Comments

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