INT176892

Context Info Confidence 0.32 First Reported 2002 Last Reported 2010 Negated 0 Speculated 3 Reported most in Body Documents 36 Total Number 39 Disease Relevance 15.55 Pain Relevance 2.58

extracellular region (MR1) endoplasmic reticulum (MR1) plasma membrane (MR1)

Anatomy Link Frequency bone marrow 2 follicles 1 fat 1 brain 1 skin 1 MR1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 402 100.00 Inflammation 397 99.76 iatrogenic 7 97.72 endometriosis 168 95.92 cytokine 339 89.32 cva 24 85.96 addiction 22 76.36 Inflammatory response 10 75.16 aspirin 2 62.32 Central nervous system 25 60.20

Disease Link Frequency Relevance Heat Mitral Valve Insufficiency 69 100.00 Prolapse 2 100.00 Sepsis 104 99.90 Flavivirus Infection 148 99.84 Myocardial Infarction 31 99.84 Endoleak 8 99.80 INFLAMMATION 406 99.76 Hematologic Neoplasms 36 99.74 Infection 1451 99.44 Mycobacterial Infection 20 98.48

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Speculation

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Disease term

When necessary, for example, in case of degenerative MR or ruptured chordae tendineae with wide prolapse, a second clip can be implanted (Figure 3).

MR Binding (implanted) of associated with prolapse and mitral valve insufficiency

1) Confidence 0.32 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2878966 Disease Relevance 0.40 Pain Relevance 0.06

All the hazards associated with diagnostic MR also apply to interventional procedures.

MR Binding (associated) of

2) Confidence 0.28 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0.07 Pain Relevance 0.05

MR is a common finding in heart failure patients.

MR Spec (finding) Binding (finding) of in heart associated with mitral valve insufficiency and myocardial infarction

3) Confidence 0.10 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC514499 Disease Relevance 0.86 Pain Relevance 0

The specificity of MR CRD4–7-Fc binding to DV sE was further examined by blot overlay.

MR Binding (binding) of

4) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.19 Pain Relevance 0.03

Terminal fucose is a reported ligand of MR and as such is the likely ligand on this source of DV antigen.

MR Spec (likely) Binding (ligand) of

5) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.12 Pain Relevance 0

To further evaluate MR as a potential DV receptor, we examined binding of DV to human MR-transfected 3T3 cells (3T3.hMR).

MR Spec (examined) Binding (binding) of

6) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0 Pain Relevance 0

We showed that MR can bind in ELISA to Japanese encephalitis virus and tick-borne encephalitis virus, both of which are reported to have glycosylated envelope proteins.

MR Binding (bind) of associated with flavivirus infection and viral meningitis

7) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.35 Pain Relevance 0.04

This, combined with the observation that MDDC express both DC-SIGN and MR [22], and our demonstration that the presence of MR alone is sufficient to confer DV binding to transfected cells, suggest that glycosylation at Asn-67 may be relevant for mediating MR binding, in addition to that of DC-SIGN.

MR Binding (binding) of

8) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0 Pain Relevance 0

Given the interaction of DV with MR described above, it was important to characterise the glycans on the human cell–produced sE, especially since we are unaware of any similar analysis in the literature.

MR Binding (interaction) of

9) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.19 Pain Relevance 0

We expanded our study of the interaction of MR with DV by demonstrating binding of CRD4-7-Fc to all four serotypes of DV.

MR Binding (interaction) of

10) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.26 Pain Relevance 0.03

These receptors recognize major histocompatibility complex class I (MHC-I) antigens, which inhibit cytotoxicity against MHC-I-expressing target cells.

major histocompatibility complex class I Binding (recognize) of

11) Confidence 0.07 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.78 Pain Relevance 0.26

In this study we show that MR binds to DV grown in mosquito cells and to recombinant mammalian cell–produced DV envelope glycoprotein.

MR Binding (binds) of

12) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.39 Pain Relevance 0.14

To our knowledge, we show for the first time that the MØ mannose receptor (MR) binds to all four serotypes of DV and specifically to the envelope glycoprotein.

MR Binding (binds) of

13) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233670 Disease Relevance 0.50 Pain Relevance 0.03

ELISA data showed that both CRD4–7-Fc and MR-HA both bound to Japanese encephalitis virus (inactivated vaccine antigen) and tick-borne encephalitis virus (inactivated, mouse brain-grown) (data not shown).

MR-HA Binding (bound) of in brain associated with flavivirus infection and viral meningitis

14) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.20 Pain Relevance 0.04

Glycan analysis, ELISA, and blot overlay assays demonstrate that MR binds via its carbohydrate recognition domains to mosquito and human cell–produced DV antigen.

MR Binding (binds) of

15) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233670 Disease Relevance 0.71 Pain Relevance 0.03

Detection of MR fusion protein binding to DV antigen ELISA.

MR Binding (binding) of

16) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.08 Pain Relevance 0.04

Fig. 12A patient with myeloma after bone marrow transplantation: The bone marrow of the lumbar spine shows a diffuse hypointense signal intensity on both plain T1-weighted (left) and fat-saturated T2-weighted (right) MR images

MR Binding (images) of in fat

17) Confidence 0.06 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.77 Pain Relevance 0.04

After the conditioning therapy for allogenic marrow transplantation, the patients reach complete aplasia, are usually isolated on a bone marrow transplantation unit and should only undergo MR imaging for vital indications.

MR Binding (imaging) of in bone marrow associated with aplasia and imagery

18) Confidence 0.06 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.65 Pain Relevance 0.14

Additional patients with hematologic malignancies may undergo MR imaging for evaluations of other pathologies, outside the bone marrow.

MR Binding (imaging) of in bone marrow associated with hematologic neoplasms and imagery

19) Confidence 0.06 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.79 Pain Relevance 0.24

A recombinant MR fusion protein (CRD4–7-Fc) was shown to recognize DV envelope (E) protein in ELISA and blot overlays, and binding was inhibited by mannose, fucose and EDTA.

MR Binding (binding) of

20) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.49 Pain Relevance 0.11

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