INT177296

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CXADR, CYP3A4) small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4)
mitochondrion organization (CXADR) enzyme binding (CYP3A4) protein complex (CXADR)
Anatomy Link Frequency
CAR 2
CXADR (Homo sapiens)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 95.52 Very High Very High Very High
Paracetamol 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 4 5.00 Very Low Very Low Very Low
Liver Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, only reference CAR(SV1) was able to bind to the CAR-response elements DR3 of CYP3A4-XREM (Fig. 3C) and DR4(I) of MDR1 -7.8 kb enhancer (data not shown) as a heterodimer with RXR?.


CAR Binding (bind) of CYP3A4 in CAR
1) Confidence 0.30 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
To investigate DNA binding of CAR variant proteins to response elements in the XREM of CYP3A4 [17] and in the -7.8 kb enhancer of MDR1 (Burk et al., to be published elsewhere), we performed electrophoretic mobility shift assays using in vitro translated RXR?
CAR Binding (binding) of CYP3A4 in CAR
2) Confidence 0.30 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.05

General Comments

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