INT17741

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 8
Speculated 1
Reported most in Body
Documents 67
Total Number 68
Disease Relevance 23.67
Pain Relevance 9.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MBP)
Anatomy Link Frequency
oligodendrocytes 10
eosinophils 6
neurons 3
astrocytes 3
T-cell 3
MBP (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 99.98 Very High Very High Very High
Pain 365 99.56 Very High Very High Very High
Inflammation 213 99.52 Very High Very High Very High
withdrawal 7 98.80 Very High Very High Very High
unmyelinated 28 98.72 Very High Very High Very High
Central nervous system 180 98.36 Very High Very High Very High
Nav1.7 340 98.22 Very High Very High Very High
Multiple sclerosis 66 96.50 Very High Very High Very High
Neuritis 25 96.40 Very High Very High Very High
Spinal cord 60 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 69 99.64 Very High Very High Very High
Cancer 102 99.60 Very High Very High Very High
INFLAMMATION 213 99.52 Very High Very High Very High
Encephalitis 11 99.42 Very High Very High Very High
Multiple Sclerosis 640 99.34 Very High Very High Very High
Disease 168 99.32 Very High Very High Very High
Alzheimer's Dementia 13 98.60 Very High Very High Very High
Stroke 257 97.24 Very High Very High Very High
Optic Neuritis 24 96.64 Very High Very High Very High
Demyelinating Disease 196 96.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cranial CT scan was normal on April 11; lumber spinal fluid contained 1 cell/microliter, 63 mg/dl of sugar, and 97 mg/dl of protein; myelin basic protein was detected, however, oligoclonal bands were absent.
Neg (absent) Gene_expression (detected) of myelin basic protein in Cranial
1) Confidence 0.78 Published 1997 Journal No To Shinkei Section Abstract Doc Link 9282374 Disease Relevance 0.92 Pain Relevance 0
In drug-dependent subjects, 68.2% produced anti-S100, 56.1% anti-NSE and 20.5% anti-MBP autoantibodies, while the incidence of autoantibodies in control healthy individuals was 4.4%, 2.2% and 0%, respectively.
Gene_expression (produced) of MBP
2) Confidence 0.73 Published 1991 Journal Int. J. Neurosci. Section Abstract Doc Link 1938173 Disease Relevance 0.84 Pain Relevance 0.16
The expression of MBP within normal samples was prominent on the surface of fibers located within axon bundles and less at nodal regions (Fig. 5A).
Gene_expression (expression) of MBP
3) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.59
In contrast, this expression of MBP was altered in painful samples (Fig. 5B,C).
Gene_expression (expression) of MBP associated with pain
4) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.62
The immune detected microdomain of MBP released from individual eosinophils within the human airway was observed to be restricted to an average of 317.5 ± 43.5??
Gene_expression (microdomain) of MBP in eosinophils
5) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
The relative area staining for PGP 9.5 with MBP was not significantly different from the relative area staining positive for MBP not containing PGP 9.5.
Neg (not) Gene_expression (containing) of MBP
6) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Specifically, the relative area of PGP 9.5 positive and MBP positive was 7.0 ± 3.0 percent compared to PGP 9.5 negative and MBP positive 5.9 ± 1.3 percent, (P > .7, n = 3 determinations from 10 distinct patients).
Gene_expression (positive) of MBP
7) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Eosinophils and extracellular MBP were identified using an antibody for MBP (data not shown).
Gene_expression (identified) of MBP in Eosinophils
8) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Similarly the microdomain of MBP released from individual eosinophils at sites along the perimeter of the airway (either luminally, or abluminally) was restricted to an average of 628.5 ± 213.9??
Gene_expression (microdomain) of MBP in eosinophils
9) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Quantification of Eosinophils and Extracellular MBP in the Vicinity of PGP 9.5 Positive Airway Neurons
Gene_expression (Quantification) of MBP in Neurons
10) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0.04
Distribution of Immunoreactive MBP and Smooth Muscle Actin in Human Airway Bronchus following Overnight Incubation with Human Eosinophils
Gene_expression (Distribution) of MBP in Muscle
11) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
In addition confocal scanning microscopy determined that the MBP deposition within the media occurred as discrete focal deposition occurring within the airway media, including the airway myocyte.
Gene_expression (deposition) of MBP in myocyte
12) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
This is seen in MBP, Q2, table 4 and in MBP, Q14, below.
Gene_expression (seen) of MBP
13) Confidence 0.64 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2186350 Disease Relevance 0.23 Pain Relevance 0
Finally, following overnight incubation, MBP could be detected easily within the smooth muscle layer.
Gene_expression (detected) of MBP in smooth muscle
14) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.08 Pain Relevance 0.04
Myelin basic protein expression
Gene_expression (expression) of Myelin basic protein
15) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.89
The expression of Nav1.7 in normal samples was seen evenly distributed within small fibers that lacked caspr and MBP staining and that most likely represent unmyelinated fibers, while expression within myelinated fibers with caspr and MBP stainings was mostly confined to the nodal site of some fibers (Fig. 5A).
Neg (lacked) Gene_expression (staining) of MBP associated with unmyelinated and nav1.7
16) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.73
For prolonged incubation, to determine the localization of eosinophils and/or immunoreactive MBP, bronchial segments were exposed to either eosinophils or MBP, and incubated for 24?
Gene_expression (exposed) of MBP in eosinophils
17) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.08 Pain Relevance 0
Later images were deconstructed into an image specific for smooth muscle actin and one specific for immunoreactive MBP using Metamorph (Molecular Devices, Sunnyvale, CA, 94089).
Gene_expression (using) of MBP in smooth muscle
18) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0.04
For prolonged incubation, to determine the localization of eosinophils and/or immunoreactive MBP, bronchial segments were exposed to either eosinophils or MBP, and incubated for 24?
Gene_expression (eosinophils) of MBP in eosinophils
19) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.08 Pain Relevance 0
For prolonged incubation, to determine the localization of eosinophils and/or immunoreactive MBP, bronchial segments were exposed to either eosinophils or MBP, and incubated for 24?
Gene_expression (/) of MBP in eosinophils
20) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.08 Pain Relevance 0

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