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Context Info
Confidence 0.41
First Reported 1991
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 10.02
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cell 5
lymphocytes 2
Digit 1
NK cell 1
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
Central grey 5 100.00 Very High Very High Very High
Central nervous system 5 99.42 Very High Very High Very High
imagery 30 98.28 Very High Very High Very High
methotrexate 18 98.24 Very High Very High Very High
cINOD 9 97.92 Very High Very High Very High
drug abuse 1 97.84 Very High Very High Very High
Arthritis 102 93.08 High High
Inflammatory response 1 92.60 High High
methadone 7 88.88 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 100.00 Very High Very High Very High
Urological Neuroanatomy 6 100.00 Very High Very High Very High
Recurrence 20 99.64 Very High Very High Very High
Central Nervous System Disease 3 99.42 Very High Very High Very High
Infection 63 99.38 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 293 99.32 Very High Very High Very High
Adverse Drug Reaction 1 99.32 Very High Very High Very High
Drug Dependence 1 97.84 Very High Very High Very High
Mycobacterial Infection 90 96.16 Very High Very High Very High
Fungal Infection 28 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of CD4+ lymphocytes populations is likely in our model; however, their function in the rejection process remains unclear.
Regulation (role) of CD4 in lymphocytes
1) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956665 Disease Relevance 0 Pain Relevance 0
No effects on changes in CD4 cell counts, viral load, or proviral DNA frequency were observed among the four dosage groups, although a decline in beta 2-microglobulin levels was apparent in the highest dosage group.
Regulation (changes) of CD4
2) Confidence 0.40 Published 1994 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 7907662 Disease Relevance 0.24 Pain Relevance 0.12
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of CD4 in NK cell associated with central grey and morphine
3) Confidence 0.37 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.44 Pain Relevance 0.57
In multivariate analyses, hard-drug use was not associated with change in CD4 cell percentage (P = 0.84), HIV RNA level (P = 0.48), or all-cause mortality (relative hazard = 1.10; 95% confidence interval, 0.61-1.98).
Regulation (change) of CD4 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.27 Published 2004 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 15483472 Disease Relevance 0.99 Pain Relevance 0.16
Cox models evaluating change in CD4+ T-cells and CD4+ percentage (rather than the absolute values on ART) versus the risk of IRIS produced similar results.
Regulation (change) of CD4 in T-cells associated with immune reconstitution inflammatory syndrome
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2895658 Disease Relevance 1.06 Pain Relevance 0
The apparent incongruity between the findings in the univariate and Cox analyses regarding the importance of these parameters in the prediction of IRIS implies complex relationships between baseline immunologic and virologic values, these parameters over time, and the development of IRIS (e.g., those with lower baseline CD4+ T-cell counts or higher HIV RNA levels were both more likely to have a more robust response to ART and to develop IRIS).
Regulation (response) of CD4 in T-cell associated with immune reconstitution inflammatory syndrome and acquired immune deficiency syndrome or hiv infection
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2895658 Disease Relevance 1.32 Pain Relevance 0.03
The treatment groups were compared using the following study variables: 1) type of infections, recurrences and severity; 2) change in CD4+ T and CD8+ T cell count; 3) change in platelet count; 4) change in TNF alpha serum levels; 5) the probability of not developing an opportunistic infection over a period of 12 months.
Regulation (change) of CD4 in T cell associated with opportunistic infections, recurrence and infection
7) Confidence 0.18 Published 1991 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 1940058 Disease Relevance 0.79 Pain Relevance 0
Poor performance on the Digit Symbol test was most strongly associated with poor MHS (OR 1.04, 95% CI 1.01-1.08, p < 0.009) and PHS (OR 1.04, 95% CI 1.01-1.08, p < 0.01) scores, controlling for CD4 count, previous AIDS diagnosis, receiving HAART, and drug abuse.
Regulation (controlling) of CD4 in Digit associated with drug abuse and acquired immune deficiency syndrome or hiv infection
8) Confidence 0.14 Published 2003 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 13678465 Disease Relevance 0.96 Pain Relevance 0.14
However when we controlled our results for the lowest CD4 count strata (CD4 < 50 cels/mm3), all the imaging differences associated with the diagnosis of TB remained statistically significant.
Regulation (controlled) of CD4 associated with mycobacterial infection and imagery
9) Confidence 0.11 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2270846 Disease Relevance 2.19 Pain Relevance 0.10
Cladribine is able to cross the blood–brain barrier (BBB)22 and is, therefore, likely to act on cells in both the periphery and CNS appearing to have a greater effect on CD4+ T cells than the CD8+ T cell population.23 The parenteral formulation of cladribine has been used extensively for the reduction of aberrant lymphocyte populations in the hematological oncology setting.
Regulation (effect) of CD4 in T cell associated with central nervous system
10) Confidence 0.09 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940747 Disease Relevance 0.45 Pain Relevance 0.08
Secondary outcomes included virological efficacy according to on-treatment (OT) analysis, changes in CD4 cell counts, incidence of AEs and lipid profiles.
Regulation (changes) of CD4
11) Confidence 0.08 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2847537 Disease Relevance 0.36 Pain Relevance 0
Phytol did not significantly alter T cell distribution, as no effect on the ratio of CD4/CD8 was seen (unpublished data).
Neg (no) Regulation (effect) of CD4 in T cell
12) Confidence 0.07 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 0.60 Pain Relevance 0.14
No alterations of CD4+/CD8, CD8+bright/CD57+, CD8+dim/ CD57+/- cells and sCD4 were observed.
Neg (No) Regulation (alterations) of CD4
13) Confidence 0.06 Published 2003 Journal Minerva Med. Section Body Doc Link 12858157 Disease Relevance 0.07 Pain Relevance 0
We observed no changes in the percentage of CD3, CD4, CD8 and CD25 positive lymphocytes in both MTX and NSAID-treated groups.
Neg (no) Regulation (changes) of CD4 in lymphocytes associated with cinod and methotrexate
14) Confidence 0.05 Published 1994 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 7487368 Disease Relevance 0.41 Pain Relevance 0.63
A set of hierarchical multiple linear regression analyses [31] were performed to investigate whether the initial CD4 value, viral response, adherence and subjective experience of adverse effects predicted the change in HRQL.
Spec (whether) Regulation (value) of CD4
15) Confidence 0.04 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1173133 Disease Relevance 0.15 Pain Relevance 0.15

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