INT177787

Context Info Confidence 0.15 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0.46

mitochondrion (MTHFD2) microtubule organizing center (BUB1B) cytoplasm (BUB1B) cytosol (BUB1B) cell proliferation (BUB1B) mitosis (BUB1B)

BUB1B (Homo sapiens) MTHFD2 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 5 98.72 cINOD 4 96.88 Inflammation 5 96.28 adenocard 1 35.48 COX2 1 5.00 metalloproteinase 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 96.28 Colon Cancer 40 93.08 Metastasis 1 62.88 Apoptosis 11 5.00 Cancer 9 5.00 Hypersensitivity 5 5.00 Adhesions 4 5.00 Leukemia 3 5.00 Stomach Cancer 2 5.00 Reprotox - General 1 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin.

BUB1B Positive_regulation (upregulated) of MTHFD2 associated with aspirin

1) Confidence 0.15 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.76 Pain Relevance 0.46

General Comments

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