INT177938

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 10.30
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (NF1) signal transduction (NF1) nucleus (NF1)
intracellular (NF1) extracellular matrix organization (NF1) cytoplasm (NF1)
Anatomy Link Frequency
blood 1
aorta 1
body 1
NF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 72.48 Quite High
cINOD 6 67.12 Quite High
palliative 1 47.24 Quite Low
lidocaine 21 25.12 Quite Low
sodium channel 1 24.08 Low Low
Inflammation 1 17.20 Low Low
imagery 14 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 542 100.00 Very High Very High Very High
Watson Syndrome 36 100.00 Very High Very High Very High
Neurofibromatosis 4 99.84 Very High Very High Very High
Cancer 117 98.68 Very High Very High Very High
Hypoglycemia 37 97.16 Very High Very High Very High
Malignant Neoplastic Disease 26 94.28 High High
Carcinoid 11 94.28 High High
Nerve Sheath Neoplasms 47 93.92 High High
Von Hippel-lindau Syndrome 1 93.88 High High
Tuberous Sclerosis 2 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biallelic inactivation of NF1 and mutations of numerous additional tumor suppressor genes within the p19ARF-MDM2-TP53 and p16INK4A-Rb signaling cascades have been identified in MPNSTs [12,13].
Negative_regulation (inactivation) of NF1 associated with cancer and watson syndrome
1) Confidence 0.43 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 1.85 Pain Relevance 0
The loss of NF1 in neurofibromatosis leads to constitutive mTOR activation.7 Finally, islet cell carcinomas also occur in approximately 12% of patients with von Hippel-Lindau disease (vHL).8 The vHL gene is located on chromosome 3p26–p25; inactivation of the vHL gene is thought to stimulate angiogenesis by promoting increased HIF-1?
Negative_regulation (loss) of NF1 associated with hypoglycemia, von hippel-lindau syndrome, neurofibromatosis and watson syndrome
2) Confidence 0.42 Published 2007 Journal Ann Surg Oncol Section Body Doc Link PMC2077912 Disease Relevance 2.28 Pain Relevance 0
In their allometric scaling study, Greve and colleagues [18] showed that across species, including mice, rats, dogs and humans, mean WSS in the infra-renal aorta decreases linearly with body mass on a log/log scale.
Negative_regulation (decreases) of WSS in body associated with stress
3) Confidence 0.37 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.85 Pain Relevance 0
Across species mean WSS in a particular artery decreases linearly with body mass, e.g., in the infra-renal aorta from 8.8 Pa in mice to 0.5 Pa in humans.
Negative_regulation (decreases) of WSS in aorta associated with stress
4) Confidence 0.37 Published 2008 Journal Med Biol Eng Comput Section Abstract Doc Link PMC2441533 Disease Relevance 0.88 Pain Relevance 0
, i.e., any slight increase and decrease in WSS is counteracted by a proportional increase and decrease in arterial diameter, respectively [21, 51, 54, 64].
Negative_regulation (decrease) of WSS associated with stress
5) Confidence 0.37 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.72 Pain Relevance 0
Determination of WSS in vivo
Negative_regulation (Determination) of WSS associated with stress
6) Confidence 0.36 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.79 Pain Relevance 0
However, the loss of NF1 gene function is not the unique molecular lesion in these tumors, inactivation of p53 and p16 gene regions seem to play a crucial role in the malignant transformation of MPNSTs [7,8].
Negative_regulation (loss) of NF1 associated with malignant neoplastic disease, cancer and watson syndrome
7) Confidence 0.30 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 1.87 Pain Relevance 0.20
In general, the anastomosis bed was affected the most with reduced peak WSS values in comparison to similar planar models, while the mean oscillatory WSS magnitude was also shown to decrease.
Negative_regulation (reduced) of WSS associated with stress
8) Confidence 0.08 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 0.40 Pain Relevance 0
In all gata morphants, the WSS is decreased due to the reduced blood viscosity.
Negative_regulation (decreased) of WSS in blood associated with stress
9) Confidence 0.01 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2773122 Disease Relevance 0.65 Pain Relevance 0

General Comments

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