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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K1) cytoskeleton (MAP3K1) cytoplasm (MAP3K1)
Anatomy Link Frequency
TK-1 1
MAP3K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 48 86.16 High High
Inflammation 1 73.72 Quite High
imagery 37 61.92 Quite High
cINOD 6 49.96 Quite Low
peripheral neuropathy 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 28 94.40 High High
Apoptosis 37 92.88 High High
Colon Cancer 1 89.60 High High
Toxicity 18 79.08 Quite High
INFLAMMATION 3 73.72 Quite High
Lung Cancer 5 72.60 Quite High
Familial Adenomatous Polyposis 5 55.12 Quite High
Polyps 1 52.44 Quite High
Recurrence 2 51.28 Quite High
Nerve Sheath Neoplasms 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, PKG activates the JNK pathway via phosphorylation and activation of MEKK1 [21,22].
Phosphorylation (phosphorylation) of MEKK1
1) Confidence 0.20 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 1.01 Pain Relevance 0.04
FLT, a thymidine nucleoside analog, undergoes the same first metabolic step as thymidine when it is 5'-monophosphorylated by the cytosolic enzyme thymidine kinase-1 (TK-1), however, the 3' substitution prevents further incorporation into DNA.
Phosphorylation (monophosphorylated) of kinase-1 in TK-1
2) Confidence 0.05 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.30 Pain Relevance 0.20

General Comments

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