INT177993

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 7.49
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CSF1R) signal transduction (CSF1R) plasma membrane (CSF1R)
Anatomy Link Frequency
macrophages 1
CSF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 288 100.00 Very High Very High Very High
Pain 29 100.00 Very High Very High Very High
Inflammation 112 96.32 Very High Very High Very High
spastic colon 5 88.20 High High
rheumatoid arthritis 16 87.28 High High
agonist 1 68.48 Quite High
Dopamine 3 68.08 Quite High
Crohn's disease 42 63.44 Quite High
cytokine 29 55.24 Quite High
headache 2 52.96 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 293 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
Injury 164 99.92 Very High Very High Very High
Affective Disorder 9 99.52 Very High Very High Very High
INFLAMMATION 137 96.32 Very High Very High Very High
Syndrome 27 95.24 Very High Very High Very High
Depression 8 92.08 High High
Adhesions 1 91.32 High High
Persian Gulf Syndrome 1 88.96 High High
Functional Bowel Disorder 5 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro studies demonstrating that the CSF1R protein mediates morphological changes in macrophages through the regulation of paxillin and focal adhesions [29].
Localization (localization) of CSF1R in macrophages associated with adhesions
1) Confidence 0.73 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.45 Pain Relevance 0.15
Resin histology and c-fms in situ hybridization
Localization (hybridization) of c-fms associated with fibromyalgia
2) Confidence 0.73 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.43 Pain Relevance 0.05
Indeed, Hudson and colleagues [28] reported on familial aggregation of ASD collectively and familial co-aggregation of FMS with other forms of ASD.
Localization (aggregation) of FMS associated with fibrositis
3) Confidence 0.54 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779444 Disease Relevance 1.68 Pain Relevance 0.59
In a more comprehensive family study, Arnold et al. [5] assessed familial aggregation of FMS with measures of tenderness and pain, and familial co-aggregation of FMS with major mood disorder.
Localization (aggregation) of FMS associated with pain, affective disorder and fibrositis
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 2.50 Pain Relevance 1.10
In a more comprehensive family study, Arnold et al. [5] assessed familial aggregation of FMS with measures of tenderness and pain, and familial co-aggregation of FMS with major mood disorder.
Localization (aggregation) of FMS associated with pain, affective disorder and fibrositis
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 2.42 Pain Relevance 1.06

General Comments

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