INT178114

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.44
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
OGE 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 1 96.00 Very High Very High Very High
antagonist 35 83.76 Quite High
Inflammation 8 68.64 Quite High
Pain 10 64.16 Quite High
ischemia 46 49.16 Quite Low
adenocard 13 28.04 Quite Low
Clonidine 35 5.00 Very Low Very Low Very Low
Angina 16 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 211 99.98 Very High Very High Very High
Breast Cancer 19 99.84 Very High Very High Very High
Cancer 161 99.68 Very High Very High Very High
Prostate Cancer 14 99.68 Very High Very High Very High
Carcinoma 10 94.24 High High
Ovarian Cancer 23 93.44 High High
Disease 249 90.64 High High
Colon Cancer 28 87.84 High High
Pancreatic Cancer 2 85.92 High High
Death 47 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COS-7 cells were treated as shown for 24 h and blotted for phosphorylated Bcl-2 (PBcl-2) before stripping and reprobing for total Bcl-2 (TBcl-2).
Positive_regulation (blotted) of Phosphorylation (phosphorylated) of Bcl-2
1) Confidence 0.49 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Bcl-2 associated with apoptosis
2) Confidence 0.32 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.39 Pain Relevance 0.06
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Bcl-2 associated with apoptosis
3) Confidence 0.32 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.39 Pain Relevance 0.06
The antiapoptotic protein Bcl-2 and inactive phosphorylated form of Bad (Figures 1 and 2) were increased in all cancer specimens, with no differences among Duke's stages, whereas the proapototic proteins Bad and Bak were decreased (Figure 2).


Neg (no) Positive_regulation (increased) of Phosphorylation (phosphorylated) of Bcl-2 associated with cancer
4) Confidence 0.24 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.59 Pain Relevance 0
This effect is associated with reduced expression level of p21 in prostate cancer cell PC3 33 or increased Bcl-2 phosphorylation in breast cancer cells 34, and multidrug resistance-associated protein 1 35, respectively.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Bcl-2 associated with breast cancer and prostate cancer
5) Confidence 0.11 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.22 Pain Relevance 0
Additionally, OGE pretreatment significantly upregulated Bcl-2 expression and Akt phosphorylation, and slightly affected the phosphorylation of mitogen-activated protein kinases including p38 MAPK and JNK.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of Bcl-2 in OGE
6) Confidence 0.10 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952314 Disease Relevance 0.49 Pain Relevance 0.03
Paclitaxel-induced apoptosis resulted in the phosphorylation of Bcl-2 that was suppressed by the addition of ET-1.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of Bcl-2 associated with apoptosis
7) Confidence 0.06 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.89 Pain Relevance 0.12
Thiol ROS scavengers such as NAC inhibit mTOR (which would be expected to induce autophagy) but decrease the phosphorylation of JNK and Bcl-2 which will inhibit autophagy, while the superoxide-generating agent menadione increases levels of LC3-II and the phosphorylation of JNK and Bcl-2.


Positive_regulation (increases) of Phosphorylation (phosphorylation) of Bcl-2
8) Confidence 0.06 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.29 Pain Relevance 0
(F) The superoxide generating agent menadione increases LC3-II and phosphorylation of JNK and Bcl-2, but has no effect on mTOR substrates or Beclin-1 expression.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Bcl-2
9) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.06 Pain Relevance 0
Menadione had the opposite effect of thiol antioxidants by enhancing JNK and Bcl-2 phosphorylation, but had no effect on mTOR activity or Beclin-1 expression (Fig. 6F).
Positive_regulation (enhancing) of Phosphorylation (phosphorylation) of Bcl-2
10) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.12 Pain Relevance 0
COS-7 cells were treated as shown for 24 h and blotted for phosphorylated Bcl-2 (PBcl-2) before stripping and reprobing for total Bcl-2 (TBcl-2).
Positive_regulation (blotted) of Phosphorylation (phosphorylated) of Bcl-2
11) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0

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