INT178201

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.92
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd40lg) extracellular space (Cd40lg) extracellular region (Cd40lg)
plasma membrane (Cd40lg)
Cd40lg (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 66 98.80 Very High Very High Very High
rheumatoid arthritis 26 82.72 Quite High
cytokine 28 82.48 Quite High
cva 4 80.24 Quite High
abatacept 2 61.64 Quite High
antagonist 2 61.20 Quite High
Infliximab 2 55.48 Quite High
tolerance 20 50.00 Quite Low
Inflammation 5 41.88 Quite Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 99.76 Very High Very High Very High
Experimental Arthritis 40 98.80 Very High Very High Very High
Bronchiolo-alveolar Adenocarcinoma 1 92.68 High High
Recurrence 2 92.40 High High
Lung Cancer 3 89.00 High High
Autoimmune Disease 15 87.72 High High
Rheumatoid Arthritis 26 82.72 Quite High
Cancer 202 81.80 Quite High
Cv General 3 Under Development 4 80.24 Quite High
Prostate Cancer 6 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of the CD40-CD154 interaction has been shown to actually induce generation of T regulatory (Treg) cells [8].
Negative_regulation (Suppression) of CD154 Binding (interaction) of
1) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.91 Pain Relevance 0.38
This therapy is highly effective in mouse models [4,18], although the overall benefit of interruption of CD40-CD154 association is reduced when Abs is administrated after disease establishment.
Negative_regulation (reduced) of CD154 Binding (association) of associated with disease
2) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.82 Pain Relevance 0.23
DCwere matured with a combination of LPS, CD40L and IFN-?
Negative_regulation (matured) of CD40L Binding (combination) of
3) Confidence 0.19 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.19 Pain Relevance 0.04

General Comments

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