INT178513

Context Info Confidence 0.35 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.80 Pain Relevance 0.04

cell proliferation (COL4A3) extracellular region (COL4A3) cell adhesion (COL4A3) structural molecule activity (COL4A3)

COL4A3 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 8 75.44 cytokine 5 5.00 chemokine 3 5.00 Inflammation 2 5.00 Pain 2 5.00 Bioavailability 2 5.00 Potency 2 5.00 spastic colon 1 5.00 Central nervous system 1 5.00 depression 1 5.00

Disease Link Frequency Relevance Heat Squamous Cell Carcinoma 3 89.84 Adhesions 4 88.40 Disease 37 86.88 Alport Syndrome 10 86.20 Renal Failure 3 71.80 Cancer 173 71.20 Metastasis 14 64.76 Melanoma 17 63.24 Renal Disease 9 55.48 Inborn Genetic Diseases 14 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

3 chain play a significant role in promoting angiogenesis, although the lack of it can also promote angiogenesis, given that the angiogenesis inhibitor tumstatin binds through this receptor [41].

tumstatin Binding (binds) of

1) Confidence 0.35 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.50 Pain Relevance 0.04

This study proved that the construct could produce a functional protein capable of trimerizing with COL4A3 and COL4A4 (Heikkilä et al. 2001).

COL4A3 Binding (trimerizing) of

2) Confidence 0.32 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 0.30 Pain Relevance 0

Figure 4 shows an example of a coexpression plot based on the number of sequence reads for a murine pSNP recently shown to affect the binding of miR-133a to a collagen precursor (Col4a3) (40).

Col4a3 Binding (binding) of

3) Confidence 0.24 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0 Pain Relevance 0

General Comments

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