INT178587

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.70
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DPYD) small molecule metabolic process (DPYD) oxidoreductase activity (DPYD)
cytoplasm (DPYD)
Anatomy Link Frequency
stem cell 1
DPYD (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 45 98.70 Very High Very High Very High
Inflammation 22 98.06 Very High Very High Very High
Arthritis 13 92.36 High High
rheumatoid arthritis 17 65.84 Quite High
cytokine 10 60.12 Quite High
Spinal cord 24 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 124 100.00 Very High Very High Very High
Hypoxia 70 100.00 Very High Very High Very High
Frailty 46 98.70 Very High Very High Very High
INFLAMMATION 19 98.06 Very High Very High Very High
Infection 16 97.46 Very High Very High Very High
Arthritis 17 92.36 High High
Death 12 85.84 High High
Htlv Types I And Ii 8 83.60 Quite High
Leukemia 4 82.08 Quite High
Targeted Disruption 1 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme acting in the catabolism of the widely used antineoplastic agent 5-fluorouracil (5FU).

Positive_regulation (splicing) of dihydropyrimidine dehydrogenase associated with toxicity
1) Confidence 0.50 Published 2010 Journal Hum Genet Section Title Doc Link PMC2955237 Disease Relevance 0.44 Pain Relevance 0
Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme acting in the catabolism of the widely used antineoplastic agent 5-fluorouracil (5FU).

Positive_regulation (causing) of DPD associated with toxicity
2) Confidence 0.47 Published 2010 Journal Hum Genet Section Title Doc Link PMC2955237 Disease Relevance 0.46 Pain Relevance 0
Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme acting in the catabolism of the widely used antineoplastic agent 5-fluorouracil (5FU).

Positive_regulation (causing) of Dihydropyrimidine dehydrogenase associated with toxicity
3) Confidence 0.47 Published 2010 Journal Hum Genet Section Title Doc Link PMC2955237 Disease Relevance 0.46 Pain Relevance 0
The homology model of human DPD was generated by manual adjustment of the sequence of the deposited crystal structure of recombinant pig DPD (PDB-ID: 1h7w; Dobritzsch et al. 2001) to that of the human enzyme using WinCoot (Emsley et al. 2010).
Positive_regulation (generated) of DPD
4) Confidence 0.41 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955237 Disease Relevance 0 Pain Relevance 0
The present study indicates that HTLV-I infection could modify the inflammatory activity of ordinary primary OA, whereby direct activation by Tax protein might account for the increased concentrations of PTHrP, sIL-2R, IL-6 and DPD in SF.
Positive_regulation (increased) of DPD associated with inflammation, osteoarthritis and infection
5) Confidence 0.22 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 2.14 Pain Relevance 0.74
The analysis of the differentially expressed genes indicated that the upregulated genes triggered by hypoxia/DHP-d can be clustered into different functional groups.
Positive_regulation (upregulated) of DHP-d associated with hypoxia
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.65 Pain Relevance 0
was induced and their siRNA transfection resulted in attenuation of hypoxic/DHP-d activated stem cell growth and related signal protein activation, including MAPK, JAK/STAT, and AKT (Figure 3E).
Positive_regulation (activation) of DHP-d in stem cell associated with hypoxia
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.54 Pain Relevance 0

General Comments

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