INT179038

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.49
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 89.60 High High
Spinal cord 81 87.28 High High
Inflammation 20 61.12 Quite High
Demyelination 2 32.08 Quite Low
Inflammatory response 5 12.04 Low Low
cytokine 15 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 54 100.00 Very High Very High Very High
Cancer 46 99.52 Very High Very High Very High
Malignant Neoplastic Disease 2 99.28 Very High Very High Very High
Spinal Cord Injury 122 99.02 Very High Very High Very High
Death 10 95.92 Very High Very High Very High
Polycystic Kidney Disease 1 93.12 High High
Reprotox - General 1 2 87.36 High High
Carcinoma 35 82.64 Quite High
Injury 34 82.36 Quite High
Transitional Cell Carcinoma 4 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of Bcl2 protein expression have been found in many different types of cancer, suggesting a possible role for Bcl2 deregulation of apoptosis and malignant tissue transformation.
Spec (possible) Positive_regulation (role) of Regulation (deregulation) of Bcl2 associated with malignant neoplastic disease, cancer and apoptosis
1) Confidence 0.39 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.34 Pain Relevance 0
Based on these evidences, we have identified in SCI proapoptotic transcriptional changes, including upregulation of proapoptotic Bax and down regulation of antiapoptotic Bcl-2, by immunohystochemical staining.
Positive_regulation (upregulation) of Regulation (regulation) of Bcl-2 associated with spinal cord injury and apoptosis
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 2.16 Pain Relevance 0.12

General Comments

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