INT179078

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
hepatocytes 6
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 47.84 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 63 99.62 Very High Very High Very High
Cancer 574 98.32 Very High Very High Very High
Colorectal Cancer 58 96.00 Very High Very High Very High
Hepatocellular Cancer 90 93.20 High High
Intestinal Cancer 2 87.16 High High
Chromosome Aberrations 2 86.84 High High
Liver Cancer 34 77.68 Quite High
Adenocarcinoma 7 67.72 Quite High
Hypertrophy 12 66.88 Quite High
Apoptosis 122 54.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of MYC overexpression on the size of adult hepatocytes depended on the duration of MYC activation.
Regulation (depended) of Gene_expression (overexpression) of MYC in hepatocytes
1) Confidence 0.62 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.12 Pain Relevance 0
To address this hypothesis, we have used the tetracycline regulatory system to generate transgenic mice in which the expression of a c-MYC human transgene can be conditionally regulated in murine hepatocytes.
Regulation (regulated) of Gene_expression (expression) of MYC in hepatocytes associated with targeted disruption
2) Confidence 0.62 Published 2004 Journal PLoS Biology Section Abstract Doc Link PMC519000 Disease Relevance 0.48 Pain Relevance 0
Thus, we have developed a transgenic model that enables us to conditionally regulate MYC expression in murine hepatocytes.
Regulation (regulate) of Gene_expression (expression) of MYC in hepatocytes associated with targeted disruption
3) Confidence 0.62 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.86 Pain Relevance 0
Complete regulation of C-MYC expression by doxycycline was previously observed to have a time scale of four days [22], [26].
Regulation (regulation) of Gene_expression (expression) of MYC
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894073 Disease Relevance 0.66 Pain Relevance 0
Conversely, MYC levels do not change, or are reduced in the NTG contingent of tumor cells, which themselves are progeny of CoCSC.
Neg (not) Regulation (change) of Gene_expression (levels) of MYC associated with cancer
5) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.57 Pain Relevance 0
If correct, our model would predict in the context of MMR deficiency, pulsatile induction of Myc or other oncogenes would have a much greater affect than continuous Myc expression.


Regulation (affect) of Gene_expression (expression) of Myc
6) Confidence 0.08 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.33 Pain Relevance 0

General Comments

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