INT179086

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.78
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
hepatocytes 6
neuroblasts 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 82.92 Quite High
cytokine 8 78.28 Quite High
Central nervous system 8 50.96 Quite High
ischemia 2 27.28 Quite Low
alcohol 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 323 98.56 Very High Very High Very High
Hyperplasia 50 98.56 Very High Very High Very High
Hepatocellular Cancer 84 98.16 Very High Very High Very High
Malignant Neoplastic Disease 25 92.84 High High
Apoptosis 107 91.24 High High
Targeted Disruption 64 88.48 High High
Disease 11 85.84 High High
INFLAMMATION 23 82.92 Quite High
Intestinal Cancer 1 80.40 Quite High
Death 10 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a related study, Gil-Perotin et al., found a p53-dependent effect on differentiationthe and they could determine that loss of p53 increased the number of Tuj1+ neuroblasts in the subventricular zone in vivo [31].
Positive_regulation (increased) of Negative_regulation (loss) of p53 in neuroblasts
1) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.93 Pain Relevance 0
We found that the ability of MYC overexpression to induce tumorigenesis in adult hepatocytes often requires the loss of p53 function.
Positive_regulation (requires) of Negative_regulation (loss) of p53 in hepatocytes
2) Confidence 0.38 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.84 Pain Relevance 0
Hence, in adult hepatocytes, loss of p53 function appears to be necessary to permit MYC activation to induce cellular proliferation and tumorigenesis.
Positive_regulation (necessary) of Negative_regulation (loss) of p53 in hepatocytes associated with hyperplasia
3) Confidence 0.38 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.83 Pain Relevance 0.03
We speculated that loss of p53 function might be similarly required for MYC activation to induce cell proliferation and tumorigenesis in hepatocytes.
Positive_regulation (required) of Negative_regulation (loss) of p53 in hepatocytes
4) Confidence 0.38 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.75 Pain Relevance 0
Transformation induced by Ras was restored upon deletion of p53.25,26

MIF receptor signalling and tumour pathogenesis

Positive_regulation (restored) of Negative_regulation (deletion) of p53 associated with cancer
5) Confidence 0.17 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.43 Pain Relevance 0.12

General Comments

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