INT179416

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4)
Anatomy Link Frequency
brain 2
Map2k4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 44 93.36 High High
amygdala 24 86.80 High High
Catecholamine 2 35.36 Quite Low
nMDA receptor 10 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Visceral pain 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 134 94.48 High High
Depression 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 5.00 Very Low Very Low Very Low
Glioma 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Depressive Disorder 2 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A gradual increase in P-Erk2 and P-JNK phosphorylation, subsequent to activation of MEK1/2 and MKK4, may have been obscured by the fact that animals were sacrificed immediately after termination of the swim.
Positive_regulation (increase) of Positive_regulation (activation) of MKK4
1) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.16 Pain Relevance 0.10
Analogous to its effects on P-MEK1/2, but much more dramatically, forced swimming enhanced the levels of P-MKK4, the immediate upstream activator of JNK, in all brain areas tested (Fig. 3, top).
Positive_regulation (enhanced) of Positive_regulation (immediate upstream activator) of MKK4 in brain
2) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.16 Pain Relevance 0.24

General Comments

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