INT179417

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.86
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4)
Anatomy Link Frequency
brain 8
Map2k4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 60 92.44 High High
Hippocampus 110 90.84 High High
analgesia 5 85.88 High High
nMDA receptor 25 79.08 Quite High
Dopamine 5 57.04 Quite High
anesthesia 5 41.48 Quite Low
halothane 5 40.72 Quite Low
Glutamate receptor 5 34.20 Quite Low
Visceral pain 10 32.96 Quite Low
ischemia 5 32.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 335 99.98 Very High Very High Very High
Anxiety Disorder 10 71.04 Quite High
Depressive Disorder 5 70.08 Quite High
Sprains And Strains 5 35.16 Quite Low
Shock 10 34.08 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

10 32.96 Quite Low
Cv Unclassified Under Development 5 32.36 Quite Low
Depression 20 5.00 Very Low Very Low Very Low
Glioma 10 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results presented establish unambiguously that forced swim stress elicits a rapid and profound but relatively transient increase in the phosphorylation (and consequently the presumed activation) of the MEK-Erk and MKK4-JNK signaling pathways in, at the least, the five brain regions examined.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
1) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.41 Pain Relevance 0.10
The results presented establish unambiguously that forced swim stress elicits a rapid and profound but relatively transient increase in the phosphorylation (and consequently the presumed activation) of the MEK-Erk and MKK4-JNK signaling pathways in, at the least, the five brain regions examined.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
2) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.40 Pain Relevance 0.10
Moreover, the magnitude of the increase in phosphorylation of MEK1/2 and MKK4 was much greater than for their cognate substrates.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MKK4
3) Confidence 0.33 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.59 Pain Relevance 0.34
Swim stress specifically and markedly enhanced the phosphorylation of the MAPKKs P-MEK1/2 and P-MKK4 in all brain regions tested without apparent alteration in the phosphorylation of P-MKK3/6.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
4) Confidence 0.33 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC526203 Disease Relevance 0.24 Pain Relevance 0.10
Swim stress increases phosphorylation of MKK4 in all brain regions
Positive_regulation (increases) of Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
5) Confidence 0.33 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.22 Pain Relevance 0.25

General Comments

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