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{| style="color: black; background-color: white;" class="wikitable"
+
{| style="color: black; background-color: white;"
| colspan="3" style="color: black; background-color: white; vertical-align: top"|
+
| style="color: black; background-color: white; vertical-align: top"|
 
{| cellpadding=3 cellspacing=0  
 
{| cellpadding=3 cellspacing=0  
 
|-
 
|-
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|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 5.1863669300
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.39
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2004
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2004|2004]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
Line 22: Line 22:
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Reported most in
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Reported most in
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| NULL
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| Body
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Documents
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Documents
Line 29: Line 29:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Total Number
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Total Number
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 30
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 30
 +
|-
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 13.77
 +
|-
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 5.73
 
|-
 
|-
 
|}
 
|}
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fontcolor=white,
 
fontcolor=white,
 
label="Binding",
 
label="Binding",
URL=Binding
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Binding"
 
];
 
];
 
node2
 
node2
Line 50: Line 56:
 
fontcolor=white,
 
fontcolor=white,
 
label="Cd14",
 
label="Cd14",
URL="Cd14"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:12475"
 
];
 
];
 
node3
 
node3
Line 58: Line 64:
 
fontcolor=white,
 
fontcolor=white,
 
label="Tlr4",
 
label="Tlr4",
URL="Tlr4"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:21898"
 
];
 
];
 
subgraph cluster_0 {
 
subgraph cluster_0 {
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{| cellspacing=5 cellpadding=2
 
{| cellspacing=5 cellpadding=2
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[plasma membrane]] ([[Cd14]], [[Tlr4]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:plasma membrane|plasma membrane]] ([[G:12475|Cd14]], [[G:21898|Tlr4]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[signal transduction]] ([[Tlr4]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:signal transduction|signal transduction]] ([[G:21898|Tlr4]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[extracellular space]] ([[Cd14]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:extracellular space|extracellular space]] ([[G:12475|Cd14]])
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[intracellular]] ([[Tlr4]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:intracellular|intracellular]] ([[G:21898|Tlr4]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[cytoplasm]] ([[Tlr4]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:cytoplasm|cytoplasm]] ([[G:21898|Tlr4]])
 
|-
 
|-
 
|}
 
|}
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{| cellpadding=3 cellspacing=0  
 
{| cellpadding=3 cellspacing=0  
 
|-
 
|-
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Mention
+
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:1485|myeloid cells]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:myeloid cells|myeloid cells]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|5
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|5
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:1449|astrocytes]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:astrocytes|astrocytes]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|4
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|4
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:613|oligodendrocytes]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:oligodendrocytes|oligodendrocytes]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|4
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|4
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:5334|MD2]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:MD2|MD2]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|2
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|2
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:173|immune cells]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:immune cells|immune cells]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
|-
 
|-
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|-
 
|-
 
|}
 
|}
 +
 
|-
 
|-
 +
|}
 +
{| cellspacing=2 cellpadding=2
 +
| style="vertical-align: top"|
 +
{| cellspacing=1 cellpadding=5 align=center
 +
|-
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Link
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Inflammation|Inflammation]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 498
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.48
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:agonist|agonist]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 94.48
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:chemokine|chemokine]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 112
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 94.04
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Inflammatory response|Inflammatory response]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 160
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 93.76
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:cytokine|cytokine]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 372
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 93.44
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Intracerebroventricular|Intracerebroventricular]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 53
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 87.72
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:peptic ulcer disease|peptic ulcer disease]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 6
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 82.20
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:COX2|COX2]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 61.28
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:tolerance|tolerance]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 47
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60.56
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:cINOD|cINOD]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 45
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 51.88
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
 +
|}
 +
|
 +
| style="vertical-align: top"|
 +
{| cellspacing=1 cellpadding=5 align=center
 +
|-
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Link
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:INFLAMMATION|INFLAMMATION]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 590
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.48
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Sepsis|Sepsis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 10
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 95.92
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Disease|Disease]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 88
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 95.52
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Urological Neuroanatomy|Urological Neuroanatomy]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 90.48
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Bacterial Infection|Bacterial Infection]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 34
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 88.68
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Hepatotoxicity|Hepatotoxicity]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 87.88
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Infection|Infection]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 246
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 87.28
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Shock|Shock]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 87.24
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Atrophic Gastritis|Atrophic Gastritis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 6
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 85.88
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Cancer|Cancer]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 33
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 85.44
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
|}
 
|}
 
|}
  
Line 120: Line 249:
 
| style="color: black; background:white; white-space:wrap;"| Key:
 
| style="color: black; background:white; white-space:wrap;"| Key:
 
| style="color: black; background:#FFFF00; border: 1px solid lightgray; white-space:wrap;"| Protein
 
| style="color: black; background:#FFFF00; border: 1px solid lightgray; white-space:wrap;"| Protein
 +
| style="color: black; background:#ADFF2F; border: 1px solid lightgray; white-space:wrap;"| Mutation
 
| style="color: black; background:#B0E0E6; border: 1px solid lightgray; white-space:wrap;"| Event
 
| style="color: black; background:#B0E0E6; border: 1px solid lightgray; white-space:wrap;"| Event
 
| style="color: black; background:#FFDEAD; border: 1px solid lightgray; white-space:wrap;"| Anatomy
 
| style="color: black; background:#FFDEAD; border: 1px solid lightgray; white-space:wrap;"| Anatomy
Line 125: Line 255:
 
| style="color: black; background:#D3D3D3; border: 1px solid lightgray; white-space:wrap;"| Speculation
 
| style="color: black; background:#D3D3D3; border: 1px solid lightgray; white-space:wrap;"| Speculation
 
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Pain term
 
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Pain term
 +
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Disease term
 
|-
 
|-
 
|}
 
|}
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">complex</span>) of <span style="color:#800000">'''TLR4'''</span> in <span style="color:#808000">myeloid cells</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">complex</span>) of [[G:21898|<span style="color:#800000">'''TLR4'''</span>]] in [[A:myeloid cells|<span style="color:#808000">myeloid cells</span>]]
 
|-
 
|-
 
|}
 
|}
Line 142: Line 273:
 
! style="color: black; background:white; white-space:nowrap;"| 1)
 
! style="color: black; background:white; white-space:nowrap;"| 1)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.394265172813272
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.39
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.22
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
|}
 
|}
 
|-
 
|-
Line 160: Line 295:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">associates</span>) of <span style="color:#800000">'''TLR4'''</span> in <span style="color:#808000">myeloid cells</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">associates</span>) of [[G:21898|<span style="color:#800000">'''TLR4'''</span>]] in [[A:myeloid cells|<span style="color:#808000">myeloid cells</span>]]
 
|-
 
|-
 
|}
 
|}
Line 167: Line 302:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 2)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.394265172813272
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.39
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.22
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
|}
 
|}
 
|-
 
|-
Line 187: Line 326:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">respond</span>) of <span style="color:#800000">'''LPS'''</span> in <span style="color:#808000">Alveolar macrophages</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">respond</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:Alveolar macrophages|<span style="color:#808000">Alveolar macrophages</span>]]
 
|-
 
|-
 
|}
 
|}
Line 194: Line 333:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 3)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.35765579744923
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.36
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.07
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.18
 
|}
 
|}
 
|-
 
|-
Line 214: Line 357:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">associates</span>) of <span style="color:#800000">'''LPS'''</span> in <span style="color:#808000">myeloid cells</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">associates</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:myeloid cells|<span style="color:#808000">myeloid cells</span>]]
 
|-
 
|-
 
|}
 
|}
Line 221: Line 364:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 4)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34379161204249
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.22
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
|}
 
|}
 
|-
 
|-
Line 241: Line 388:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">associates</span>) of <span style="color:#800000">'''TLR4'''</span> in <span style="color:#808000">myeloid cells</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">associates</span>) of [[G:21898|<span style="color:#800000">'''TLR4'''</span>]] in [[A:myeloid cells|<span style="color:#808000">myeloid cells</span>]]
 
|-
 
|-
 
|}
 
|}
Line 248: Line 395:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 5)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34379161204249
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.22
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
|}
 
|}
 
|-
 
|-
Line 268: Line 419:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">complex</span>) of <span style="color:#800000">'''LPS'''</span> in <span style="color:#808000">myeloid cells</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">complex</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:myeloid cells|<span style="color:#808000">myeloid cells</span>]]
 
|-
 
|-
 
|}
 
|}
Line 275: Line 426:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 6)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34379161204249
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855719 PMC2855719]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.22
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
|}
 
|}
 
|-
 
|-
Line 295: Line 450:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> Neg (not) <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">act</span>) of <span style="color:#800000">'''LPS'''</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] Neg (not) [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">act</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 302: Line 457:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 7)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.315716468113894
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.32
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2004
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2004|2004]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J Neuroinflammation|J Neuroinflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC527876 PMC527876]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC527876 PMC527876]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.30
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.27
 
|}
 
|}
 
|-
 
|-
Line 322: Line 481:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''TLR4'''</span> in <span style="color:#808000">oligodendrocytes</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">binds</span>) of [[G:21898|<span style="color:#800000">'''TLR4'''</span>]] in [[A:oligodendrocytes|<span style="color:#808000">oligodendrocytes</span>]]
 
|-
 
|-
 
|}
 
|}
Line 329: Line 488:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 8)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.230413909445133
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.23
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2008
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2008|2008]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J Neuroinflammation|J Neuroinflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2409311 PMC2409311]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2409311 PMC2409311]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.35
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.23
 
|}
 
|}
 
|-
 
|-
Line 349: Line 512:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''toll-like receptor 4'''</span> in <span style="color:#808000">oligodendrocytes</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">binds</span>) of [[G:21898|<span style="color:#800000">'''toll-like receptor 4'''</span>]] in [[A:oligodendrocytes|<span style="color:#808000">oligodendrocytes</span>]]
 
|-
 
|-
 
|}
 
|}
Line 356: Line 519:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 9)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.230413909445133
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.23
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2008
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2008|2008]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J Neuroinflammation|J Neuroinflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2409311 PMC2409311]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2409311 PMC2409311]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.35
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.23
 
|}
 
|}
 
|-
 
|-
Line 376: Line 543:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''CD14'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">complex</span>) of <span style="color:#800000">'''LPS'''</span> in <span style="color:#808000">oligodendrocytes</span>
+
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">complex</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:oligodendrocytes|<span style="color:#808000">oligodendrocytes</span>]]
 
|-
 
|-
 
|}
 
|}
Line 383: Line 550:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
! style="color: black; background:white; white-space:nowrap;"| 1)
+
! style="color: black; background:white; white-space:nowrap;"| 10)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.200916476593462
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2008
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2008|2008]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J Neuroinflammation|J Neuroinflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2409311 PMC2409311]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2409311 PMC2409311]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.17
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| The <span style="background-color:#FFFF00">LPS</span>-<span style="background-color:#FFFF00">CD14</span> <span style="background-color:#B0E0E6">complex</span>, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, <span style="background-color:#FFDEAD">oligodendrocytes</span> or cortical neurons [20].
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">complex</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:oligodendrocytes|<span style="color:#808000">oligodendrocytes</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 11)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2008|2008]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J Neuroinflammation|J Neuroinflammation]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2409311 PMC2409311]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.17
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| A receptor complex comprising of Toll-like receptor 4 (TLR4), <span style="background-color:#FFFF00">CD14</span> and MD-2 on the cell membrane of host <span style="background-color:#FFDEAD">immune cells</span> <span style="background-color:#B0E0E6">binds</span> <span style="background-color:#FFFF00">LPS</span> [8].
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">binds</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:immune cells|<span style="color:#808000">immune cells</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 12)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.16
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2943929 PMC2943929]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.06
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.39
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| <span style="background-color:#FFFF00">CD14</span> acts as a co-<span style="background-color:#B0E0E6">receptor</span> for <span style="background-color:#FFFF00">TLR4</span> and confers responsiveness to LPS, a component of the cell wall of most Gram-negative bacteria.
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">receptor</span>) of [[G:21898|<span style="color:#800000">'''TLR4'''</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 13)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.15
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Infect Dis|BMC Infect Dis]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC1351185 PMC1351185]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.33
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.04
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| The <span style="background-color:#B0E0E6">binding</span> of <span style="background-color:#FFFF00">LPS</span> to <span style="background-color:#FFFF00">CD14</span>/LPS-binding protein and Toll-like receptor-4 triggers multiple signal cascades that activate nuclear factor-?
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">binding</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 14)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.14
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2006|2006]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Environ Health Perspect|Environ Health Perspect]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC1440772 PMC1440772]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.24
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.14
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| After forming a complex with the LPS- binding protein, <span style="background-color:#FFFF00">LPS</span> <span style="background-color:#B0E0E6">interacts</span> with a membrane molecule, <span style="background-color:#FFFF00">CD14</span> and <span style="background-color:#FFDEAD">MD2</span> [10–12].
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">interacts</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:MD2|<span style="color:#808000">MD2</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 15)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.12
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2007|2007]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Journal of Clinical Biochemistry and Nutrition|Journal of Clinical Biochemistry and Nutrition]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2291505 PMC2291505]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.22
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.32
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| <span style="background-color:#B0E0E6">Binding</span> of <span style="background-color:#FFFF00">LPS</span> to <span style="background-color:#FFFF00">CD14</span> activates TLR4.
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">Binding</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 16)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J Neuroinflammation|J Neuroinflammation]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC3002338 PMC3002338]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.34
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.22
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| <span style="background-color:#FFFF00">CD14</span> <span style="background-color:#B0E0E6">forms</span> a complex with LPS and the <span style="background-color:#FFFF00">LPS</span>-binding protein (LBP) (figure 1) [19].
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">forms</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 17)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Infect Dis|BMC Infect Dis]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC1351185 PMC1351185]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.44
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.07
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| Soluble <span style="background-color:#FFFF00">CD14</span> <span style="background-color:#B0E0E6">binds</span> to <span style="background-color:#FFFF00">LPS</span> and facilitates its signaling, and this study has shown that CD14 promoter polymorphism is associated with the <span style="background-color:#FFA07A">disease</span> outcome.
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">binds</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] associated with <span style="color:#FF0000">'''disease'''</span>
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 18)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.10
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2007|2007]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Journal of Clinical Biochemistry and Nutrition|Journal of Clinical Biochemistry and Nutrition]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2291505 PMC2291505]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.74
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| The <span style="background-color:#FFDEAD">epithelial cells</span> are dependent on <span style="background-color:#FFFF00">sCD14</span> for <span style="background-color:#FFFF00">LPS</span> <span style="background-color:#B0E0E6">recognition</span> [45].
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''sCD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">recognition</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]] in [[A:epithelial cells|<span style="color:#808000">epithelial cells</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 19)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.09
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Infect Dis|BMC Infect Dis]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC1351185 PMC1351185]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.14
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.03
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| <span style="background-color:#FFFF00">CD14</span> <span style="background-color:#B0E0E6">forms</span> a complex with <span style="background-color:#FFFF00">LPS</span> and the LPS-binding protein (LBP) (figure 1) [19].
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:12475|<span style="color:#800000">'''CD14'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">forms</span>) of [[G:21898|<span style="color:#800000">'''LPS'''</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 20)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.09
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Infect Dis|BMC Infect Dis]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC1351185 PMC1351185]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.39
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.04
 
|}
 
|}
 
|-
 
|-

Latest revision as of 12:05, 20 September 2012

Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 13.77
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd14, Tlr4) signal transduction (Tlr4) extracellular space (Cd14)
intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
myeloid cells 5
astrocytes 4
oligodendrocytes 4
MD2 2
immune cells 1
Cd14 (Mus musculus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 498 99.48 Very High Very High Very High
agonist 3 94.48 High High
chemokine 112 94.04 High High
Inflammatory response 160 93.76 High High
cytokine 372 93.44 High High
Intracerebroventricular 53 87.72 High High
peptic ulcer disease 6 82.20 Quite High
COX2 2 61.28 Quite High
tolerance 47 60.56 Quite High
cINOD 45 51.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 590 99.48 Very High Very High Very High
Sepsis 10 95.92 Very High Very High Very High
Disease 88 95.52 Very High Very High Very High
Urological Neuroanatomy 3 90.48 High High
Bacterial Infection 34 88.68 High High
Hepatotoxicity 9 87.88 High High
Infection 246 87.28 High High
Shock 2 87.24 High High
Atrophic Gastritis 6 85.88 High High
Cancer 33 85.44 High High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (complex) of TLR4 in myeloid cells
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.22 Pain Relevance 0.20
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of TLR4 in myeloid cells
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.22 Pain Relevance 0.20
Alveolar macrophages, which express both CD14 and TLR4 [22] and are major producers of TNF, may not require CD14 to respond to low dose R-LPS as previously found with peritoneal macrophages [14].
CD14 Binding (respond) of LPS in Alveolar macrophages
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.07 Pain Relevance 0.18
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of LPS in myeloid cells
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.22 Pain Relevance 0.20
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of TLR4 in myeloid cells
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.22 Pain Relevance 0.20
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (complex) of LPS in myeloid cells
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.22 Pain Relevance 0.20
Membrane-anchored CD14 is now thought to act a co-receptor for LPS but not to initiate intracellular signaling cascades.
CD14 Neg (not) Binding (act) of LPS
7) Confidence 0.32 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.30 Pain Relevance 0.27
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (binds) of TLR4 in oligodendrocytes
8) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.35 Pain Relevance 0.23
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (binds) of toll-like receptor 4 in oligodendrocytes
9) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.35 Pain Relevance 0.23
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (complex) of LPS in oligodendrocytes
10) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.34 Pain Relevance 0.17
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (complex) of LPS in oligodendrocytes
11) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.34 Pain Relevance 0.17
A receptor complex comprising of Toll-like receptor 4 (TLR4), CD14 and MD-2 on the cell membrane of host immune cells binds LPS [8].
CD14 Binding (binds) of LPS in immune cells
12) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 1.06 Pain Relevance 0.39
CD14 acts as a co-receptor for TLR4 and confers responsiveness to LPS, a component of the cell wall of most Gram-negative bacteria.
CD14 Binding (receptor) of TLR4
13) Confidence 0.15 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.33 Pain Relevance 0.04
The binding of LPS to CD14/LPS-binding protein and Toll-like receptor-4 triggers multiple signal cascades that activate nuclear factor-?
CD14 Binding (binding) of LPS
14) Confidence 0.14 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 1.24 Pain Relevance 0.14
After forming a complex with the LPS- binding protein, LPS interacts with a membrane molecule, CD14 and MD2 [10–12].
CD14 Binding (interacts) of LPS in MD2
15) Confidence 0.12 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 1.22 Pain Relevance 0.32
Binding of LPS to CD14 activates TLR4.
CD14 Binding (Binding) of LPS
16) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.34 Pain Relevance 0.22
CD14 forms a complex with LPS and the LPS-binding protein (LBP) (figure 1) [19].
CD14 Binding (forms) of LPS
17) Confidence 0.11 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.44 Pain Relevance 0.07
Soluble CD14 binds to LPS and facilitates its signaling, and this study has shown that CD14 promoter polymorphism is associated with the disease outcome.
CD14 Binding (binds) of LPS associated with disease
18) Confidence 0.10 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 0.74 Pain Relevance 0
The epithelial cells are dependent on sCD14 for LPS recognition [45].
sCD14 Binding (recognition) of LPS in epithelial cells
19) Confidence 0.09 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.14 Pain Relevance 0.03
CD14 forms a complex with LPS and the LPS-binding protein (LBP) (figure 1) [19].
CD14 Binding (forms) of LPS
20) Confidence 0.09 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.39 Pain Relevance 0.04

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