INT179502

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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.200916476593462
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.200916476593462

Revision as of 21:54, 22 August 2012

Context Info
Confidence 5.1863669300
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in NULL
Documents 29
Total Number 30

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plasma membrane (Cd14, Tlr4) signal transduction (Tlr4) extracellular space (Cd14)
intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Mention Frequency
myeloid cells 5
astrocytes 4
oligodendrocytes 4
MD2 2
immune cells 1
Cd14 (Mus musculus)
Tlr4 (Mus musculus)

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (complex) of TLR4 in myeloid cells
1) Confidence 0.394265172813272 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of TLR4 in myeloid cells
2) Confidence 0.394265172813272 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
Alveolar macrophages, which express both CD14 and TLR4 [22] and are major producers of TNF, may not require CD14 to respond to low dose R-LPS as previously found with peritoneal macrophages [14].
CD14 Binding (respond) of LPS in Alveolar macrophages
3) Confidence 0.35765579744923 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of LPS in myeloid cells
4) Confidence 0.34379161204249 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of TLR4 in myeloid cells
5) Confidence 0.34379161204249 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (complex) of LPS in myeloid cells
6) Confidence 0.34379161204249 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
Membrane-anchored CD14 is now thought to act a co-receptor for LPS but not to initiate intracellular signaling cascades.
CD14 Neg (not) Binding (act) of LPS
7) Confidence 0.315716468113894 Published 2004 Journal N/A Section N/A Doc Link PMC527876
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (binds) of TLR4 in oligodendrocytes
8) Confidence 0.230413909445133 Published 2008 Journal N/A Section N/A Doc Link PMC2409311
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (binds) of toll-like receptor 4 in oligodendrocytes
9) Confidence 0.230413909445133 Published 2008 Journal N/A Section N/A Doc Link PMC2409311
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (complex) of LPS in oligodendrocytes
10) Confidence 0.200916476593462 Published 2008 Journal N/A Section N/A Doc Link PMC2409311

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