INT179502

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Context Info
Confidence 5.1863669300
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in NULL
Documents 29
Total Number 30
Disease Relevance 13.76588
Pain Relevance 10.7374

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd14, Tlr4) signal transduction (Tlr4) extracellular space (Cd14)
intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Mention Frequency
myeloid cells 5
astrocytes 4
oligodendrocytes 4
MD2 2
immune cells 1
Cd14 (Mus musculus)
Tlr4 (Mus musculus)
Pain Term Frequency Confidence Heat
Inflammation 498 99.48 Very High Very High Very High
agonist 3 94.48 High High
chemokine 112 94.04 High High
Inflammatory response 160 93.76 High High
cytokine 372 93.44 High High
Intracerebroventricular 53 87.72 High High
peptic ulcer disease 6 82.2 Quite High
COX2 2 61.28 Quite High
tolerance 47 60.56 Quite High
cINOD 45 51.88 Quite High
Disease Term Frequency Confidence Heat
INFLAMMATION 590 99.48 Very High Very High Very High
Sepsis 10 95.92 Very High Very High Very High
Disease 88 95.52 Very High Very High Very High
Urological Neuroanatomy 3 90.48 High High
Bacterial Infection 34 88.68 High High
Hepatotoxicity 9 87.88 High High
Infection 246 87.28 High High
Shock 2 87.24 High High
Atrophic Gastritis 6 85.88 High High
Cancer 33 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (complex) of TLR4 in myeloid cells
1) Confidence 0.394265172813272 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of TLR4 in myeloid cells
2) Confidence 0.394265172813272 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
Alveolar macrophages, which express both CD14 and TLR4 [22] and are major producers of TNF, may not require CD14 to respond to low dose R-LPS as previously found with peritoneal macrophages [14].
CD14 Binding (respond) of LPS in Alveolar macrophages
3) Confidence 0.35765579744923 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of LPS in myeloid cells
4) Confidence 0.34379161204249 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (associates) of TLR4 in myeloid cells
5) Confidence 0.34379161204249 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
CD14 Binding (complex) of LPS in myeloid cells
6) Confidence 0.34379161204249 Published 2010 Journal N/A Section N/A Doc Link PMC2855719
Membrane-anchored CD14 is now thought to act a co-receptor for LPS but not to initiate intracellular signaling cascades.
CD14 Neg (not) Binding (act) of LPS
7) Confidence 0.315716468113894 Published 2004 Journal N/A Section N/A Doc Link PMC527876
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (binds) of TLR4 in oligodendrocytes
8) Confidence 0.230413909445133 Published 2008 Journal N/A Section N/A Doc Link PMC2409311
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (binds) of toll-like receptor 4 in oligodendrocytes
9) Confidence 0.230413909445133 Published 2008 Journal N/A Section N/A Doc Link PMC2409311
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (complex) of LPS in oligodendrocytes
10) Confidence 0.200916476593462 Published 2008 Journal N/A Section N/A Doc Link PMC2409311
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
CD14 Binding (complex) of LPS in oligodendrocytes
11) Confidence 0.200916476593462 Published 2008 Journal N/A Section N/A Doc Link PMC2409311
A receptor complex comprising of Toll-like receptor 4 (TLR4), CD14 and MD-2 on the cell membrane of host immune cells binds LPS [8].
CD14 Binding (binds) of LPS in immune cells
12) Confidence 0.161131976662899 Published 2010 Journal N/A Section N/A Doc Link PMC2943929
CD14 acts as a co-receptor for TLR4 and confers responsiveness to LPS, a component of the cell wall of most Gram-negative bacteria.
CD14 Binding (receptor) of TLR4
13) Confidence 0.145872030040176 Published 2005 Journal N/A Section N/A Doc Link PMC1351185
The binding of LPS to CD14/LPS-binding protein and Toll-like receptor-4 triggers multiple signal cascades that activate nuclear factor-?
CD14 Binding (binding) of LPS
14) Confidence 0.138372229274105 Published 2006 Journal N/A Section N/A Doc Link PMC1440772
After forming a complex with the LPS- binding protein, LPS interacts with a membrane molecule, CD14 and MD2 [10–12].
CD14 Binding (interacts) of LPS in MD2
15) Confidence 0.118293696420382 Published 2007 Journal N/A Section N/A Doc Link PMC2291505
Binding of LPS to CD14 activates TLR4.
CD14 Binding (Binding) of LPS
16) Confidence 0.10997701885955 Published 2010 Journal N/A Section N/A Doc Link PMC3002338
CD14 forms a complex with LPS and the LPS-binding protein (LBP) (figure 1) [19].
CD14 Binding (forms) of LPS
17) Confidence 0.10846894541449 Published 2005 Journal N/A Section N/A Doc Link PMC1351185
Soluble CD14 binds to LPS and facilitates its signaling, and this study has shown that CD14 promoter polymorphism is associated with the disease outcome.
CD14 Binding (binds) of LPS
18) Confidence 0.103149817410043 Published 2007 Journal N/A Section N/A Doc Link PMC2291505
The epithelial cells are dependent on sCD14 for LPS recognition [45].
sCD14 Binding (recognition) of LPS in epithelial cells
19) Confidence 0.0945828243831663 Published 2005 Journal N/A Section N/A Doc Link PMC1351185
CD14 forms a complex with LPS and the LPS-binding protein (LBP) (figure 1) [19].
CD14 Binding (forms) of LPS
20) Confidence 0.0945828243831663 Published 2005 Journal N/A Section N/A Doc Link PMC1351185

General Comments

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