INT17961

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Context Info
Confidence 0.25
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.86
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
spinal cord 2
liver 1
platelets 1
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 99.64 Very High Very High Very High
Spinal cord 8 99.40 Very High Very High Very High
COX-2 inhibitor 6 99.32 Very High Very High Very High
Paracetamol 18 98.98 Very High Very High Very High
Analgesic 2 84.96 Quite High
Inflammation 28 76.84 Quite High
Kinase C 225 67.04 Quite High
Arthritis 2 65.92 Quite High
cytokine 17 34.56 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.44 Very High Very High Very High
Motor Neuron Diseases 14 99.26 Very High Very High Very High
Cancer 169 98.68 Very High Very High Very High
Targeted Disruption 19 98.60 Very High Very High Very High
Colon Cancer 58 98.08 Very High Very High Very High
Toxicity 6 97.70 Very High Very High Very High
Nephrotoxicity 4 93.84 High High
Gliosis 2 89.28 High High
Overdose 1 88.40 High High
Death 6 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac, as well as the selective COX-2 inhibitors, rofecoxib and celecoxib reduced cPLA2 immunoreactivity in the lumbar spinal cord of G93A transgenic mice.
Regulation (immunoreactivity) of cPLA2 in spinal cord associated with targeted disruption, cox-2 inhibitor and spinal cord
1) Confidence 0.25 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15816863 Disease Relevance 1.01 Pain Relevance 0.37
The aim of this study was to investigate the roles of cPLA2, COX-2, mPGES-1, and 15-PGDH in tumor progression.


Spec (investigate) Regulation (roles) of cPLA2 associated with cancer
2) Confidence 0.23 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2908865 Disease Relevance 0.67 Pain Relevance 0
COX-2 immunoreactivity was increased in lumbar spinal cord sections from both familial ALS (FALS) and sporadic ALS (SALS) as compared to controls, and cPLA2 immunoreactivity was increased in a patient with FALS.
Regulation (immunoreactivity) of cPLA2 in spinal cord associated with motor neuron diseases and spinal cord
3) Confidence 0.22 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15816863 Disease Relevance 1.03 Pain Relevance 0.34
The best described signaling properties reported for C1P include, on the one hand, a positive effect on cell proliferation and cell survival [4,5] and, on the other hand, the control of cytosolic phospholipase A2 (cPLA2) activity [6-9].
Regulation (control) of cPLA2
4) Confidence 0.15 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.15 Pain Relevance 0
reflecting changes in COX-2, cPLA2, and inactivating enzymes, the
Regulation (changes) of cPLA2
5) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.56 Pain Relevance 0.08
Of these, the two Ca2+-dependent isoforms, secretory (sPLA2) and cytosolic phospholipase A2 (cPLA2), are targets for new anti-inflammatory drugs.
Regulation (targets) of cytosolic phospholipase A2 associated with inflammation and cinod
6) Confidence 0.03 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989628 Disease Relevance 0.29 Pain Relevance 0.20
Hepatotoxic doses of acetaminophen cause widespread alkylation of liver and early loss of cytosolic Ca2+ regulation.
Regulation (regulation) of cytosolic in liver associated with paracetamol
7) Confidence 0.03 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1957310 Disease Relevance 0.36 Pain Relevance 0.31
Associated with target organ toxicity is selective arylation of proteins, with a 58-kDa acetaminophen binding protein (58-ABP) being the most prominent cytosolic target.
Regulation (target) of cytosolic associated with toxicity and paracetamol
8) Confidence 0.02 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8937897 Disease Relevance 0.73 Pain Relevance 0.81
Fura-2-loaded platelets (1 × 108/ml), prepared as described (33), were used to measure changes in cytosolic [Ca2+]i by calibrated ratio fluorimetry.
Regulation (changes) of cytosolic in platelets
9) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.06 Pain Relevance 0.19

General Comments

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