INT179693

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.02
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DAK) lyase activity (DAK)
Anatomy Link Frequency
plasma 2
red blood cells 2
blood 1
fat 1
colon 1
DAK (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 547 97.64 Very High Very High Very High
Eae 8 97.24 Very High Very High Very High
antidepressant 43 96.04 Very High Very High Very High
Inflammation 388 85.68 High High
cytokine 208 75.44 Quite High
dexamethasone 7 71.64 Quite High
cINOD 47 53.16 Quite High
Arthritis 3 38.36 Quite Low
imagery 12 37.28 Quite Low
COX2 1 22.68 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 34 100.00 Very High Very High Very High
Depression 531 98.64 Very High Very High Very High
Cognitive Disorder 119 98.36 Very High Very High Very High
Post-partum Depression 63 98.08 Very High Very High Very High
Neurodegenerative Disease 23 97.44 Very High Very High Very High
Arrhythmia Under Development 20 94.60 High High
Disease 274 92.52 High High
Apoptosis 4 91.80 High High
Obesity 16 89.32 High High
Ventricular Tachycardia 10 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Logistic regression analysis indicated that a 1% increase in plasma DHA was associated with a 59% reduction in the reporting of depressive symptoms [24].
Positive_regulation (increase) of DHA in plasma associated with depression
1) Confidence 0.04 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 1.10 Pain Relevance 0.20
This intervention increased the levels of EPA and DHA in the red blood cells in the actively treated group from 3.5±0.1% to 7.6±0.3%.
Positive_regulation (increased) of DHA in red blood cells
2) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.53 Pain Relevance 0
After ingestion of purified DHA, blood levels of DHA increased.
Positive_regulation (increased) of DHA in blood
3) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.15 Pain Relevance 0
Another randomized study using 1.8 g/day EPA–DHA in a similar population of 200 patients saw an increase of EPA and DHA from 4.7% to 8.3% in the patients' red blood cells (Raitt et al 2005).
Positive_regulation (increase) of DHA in red blood cells
4) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.34 Pain Relevance 0
After supplementation with EPA, but not with DHA, levels in docosapentaenoic acid increased.
Neg (not) Positive_regulation (increased) of DHA
5) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.19 Pain Relevance 0
No study using purified EPA found increases in DHA, strongly arguing against EPA being metabolized to DHA in large amounts.
Positive_regulation (increases) of DHA
6) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.15 Pain Relevance 0
For example, adult rats fed an n-3 PUFA-deficient diet beginning at weaning, which resulted in brain DHA levels 36% lower than controls, exhibited more time immobile in the forced swim test [204].
Positive_regulation (resulted) of DHA in brain associated with eae
7) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.11 Pain Relevance 0.25
Furthermore, selectively increasing DHA from fat-1 transgene expression has provided additional evidence of these DHA neuroprotective effects in adult mice [149].
Positive_regulation (increasing) of DHA in fat
8) Confidence 0.01 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 1.03 Pain Relevance 0.10
clearance by upregulating Akt pathway activity [166].DHA can suppress JNK and GSK3, two important tau kinases that promote tau pathology and neurofibrillary tangles [137, 161].
Positive_regulation (upregulating) of DHA
9) Confidence 0.01 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.52 Pain Relevance 0.04
In the Adelaide Mothers' and Babies' Iron Trial, a 1% increase in plasma DHA was related to a 59% decrease in depressive symptoms postpartum [57].
Positive_regulation (increase) of DHA in plasma associated with depression
10) Confidence 0.01 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 0.57 Pain Relevance 0.23
Babies whose mothers had high levels of DHA during pregnancy exhibited more mature sleep patterns as neonates.
Positive_regulation (levels) of DHA
11) Confidence 0.01 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 0.51 Pain Relevance 0.19
In a study of infant sleep, mothers with high levels of DHA during pregnancy had babies who exhibited a more mature sleep pattern in the first few days of life [71].
Positive_regulation (levels) of DHA
12) Confidence 0.01 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 0.54 Pain Relevance 0.23
Kelley et al. [20] reported a reduction in NK-cell activity using 6 g DHA/day over 12 weeks and this was also associated with an increase in DHA (2.3 to 7.4% of total fatty acids) in MNL.
Positive_regulation (increase) of DHA
13) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.10 Pain Relevance 0
We have explicitly chosen to use EPA instead of DHA since the proportion DHA in the colon mucosa of IBD patients was already higher as compared to control subjects [4, 5, 7].
Positive_regulation (higher) of DHA in colon associated with inflammatory bowel disease
14) Confidence 0.00 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.16 Pain Relevance 0.18

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