INT179797

Context Info Confidence 0.23 First Reported 2004 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.12 Pain Relevance 1.24

extracellular space (Il11) extracellular region (Il11) cytoplasm (Il11)

Il11 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 128 99.24 visual analogue scale 12 98.72 Pain 12 98.56 metalloproteinase 20 75.12 Inflammatory response 12 63.44 Inflammation 8 59.04 rheumatoid arthritis 82 53.84 Arthritis 4 50.00 ketamine 4 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Pain 12 98.56 Disease 58 95.92 INFLAMMATION 20 63.44 Rheumatoid Arthritis 84 53.84 Arthritis 2 19.96 Leukemia 6 5.00 Cancer 4 5.00 Arthropathy 4 5.00 Anaemia 2 5.00 Necrosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Given that IL-11 is a secreted cytokine with autocrine and paracrine activity, a direct effect on ECM molecule transcription would be dependent on coincident expression patterns of the ECM molecules, IL-11 and its receptors.

Regulation (dependent) of IL-11 associated with cytokine

1) Confidence 0.23 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.11

We further investigated whether IL-6 family cytokines levels can change and found that the concentrations of IL-6 and IL-11 significantly decreased as DAS28 decreased (Table 4).

Regulation (concentrations) of IL-11 associated with cytokine

2) Confidence 0.17 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.83 Pain Relevance 0.54

By elucidating the role of IL-11 regulated genes in decidualization, future work may identify potential new targets for the manipulation of human fertility.

Regulation (regulated) of IL-11

3) Confidence 0.14 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.13

Serum concentrations of IL-11 and LIF were not significantly correlated with CRP levels, DAS28, or pain VAS (Table 2).

Regulation (concentrations) of IL-11 associated with pain and visual analogue scale

4) Confidence 0.08 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.29 Pain Relevance 0.46

General Comments

This test has worked.