INT179905

Context Info Confidence 0.19 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.92 Pain Relevance 0

cytoplasm (ELANE, SRI) signal transduction (SRI) transport (SRI) peptidase activity (ELANE) extracellular region (ELANE) plasma membrane (SRI)

Anatomy Link Frequency neutrophil 2 ELANE (Homo sapiens) SRI (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 5.00 rheumatoid arthritis 1 5.00 Crohn's disease 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Neutrophil Disorders 22 100.00 Neutropenia 3 96.24 Disease 3 82.00 Agranulocytosis 17 77.00 Toxicity 2 50.00 Leukemia 2 14.16 Lymphatic System Cancer 7 9.04 INFLAMMATION 4 5.00 Inflammatory Bowel Disease 3 5.00 Arthritis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In theory, SCN and CN are caused by an accumulation of neutrophil elastase, leading to an inactivation of G-CSF and a negative feedback on granulopoiesis, which causes neutropenia.

Positive_regulation (accumulation) of elastase in neutrophil Positive_regulation (caused) of SCN associated with neutropenia and neutrophil disorders

1) Confidence 0.19 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.92 Pain Relevance 0

General Comments

This test has worked.