INT18011

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Context Info
Confidence 0.50
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 60
Total Number 62
Disease Relevance 31.88
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
Anatomy Link Frequency
tail 2
CSF 2
plasma 1
nephron 1
blood 1
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 80 99.88 Very High Very High Very High
cINOD 54 99.52 Very High Very High Very High
cytokine 16 99.52 Very High Very High Very High
anesthesia 1 99.18 Very High Very High Very High
halothane 1 98.96 Very High Very High Very High
alcohol 38 98.44 Very High Very High Very High
Acupuncture 8 98.34 Very High Very High Very High
COX2 23 97.60 Very High Very High Very High
cva 70 97.30 Very High Very High Very High
Multiple sclerosis 6 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 2088 100.00 Very High Very High Very High
Manic Depressive Disorder 744 100.00 Very High Very High Very High
Thrombocytopenia 1 99.96 Very High Very High Very High
INFLAMMATION 137 99.88 Very High Very High Very High
Celiac Disease 12 99.84 Very High Very High Very High
Thyroid Disease 9 99.84 Very High Very High Very High
Heart Rate Under Development 89 99.58 Very High Very High Very High
Cancer 773 99.52 Very High Very High Very High
Pressure And Volume Under Development 38 99.44 Very High Very High Very High
Reprotox - General 3 7 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous work showed that the banding process of docking minimally affected mature cows' behavior and physiology, but cutting off the necrotic tail increased haptoglobin.
Positive_regulation (increased) of haptoglobin in tail
1) Confidence 0.50 Published 2002 Journal J. Dairy Sci. Section Abstract Doc Link 12487452 Disease Relevance 0.07 Pain Relevance 0.07
A similar effect was observed for haptoglobin mRNA, used as a control for acute-phase protein expression.
Positive_regulation (effect) of haptoglobin
2) Confidence 0.45 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.16 Pain Relevance 0.13
Patients developed moderate increases of serum levels of soluble interleukin-2 receptors, beta 2-microglobin, and immunoglobulin M (IgM), and of the acute phase reactants, C-reactive protein (CRP), fibrinogen, and haptoglobin.
Positive_regulation (increases) of haptoglobin
3) Confidence 0.43 Published 1991 Journal J. Clin. Oncol. Section Abstract Doc Link 1960553 Disease Relevance 0.41 Pain Relevance 0.10
Rectal temperatures were significantly elevated until 5 days after treatment, cortisol was elevated until 3 days after treatment, haptoglobin for at least 7 days after treatment and the neutrophil to lymphocyte ratio until 4 days after treatment.
Positive_regulation (elevated) of haptoglobin in lymphocyte
4) Confidence 0.42 Published 2009 Journal Aust. Vet. J. Section Body Doc Link 19178472 Disease Relevance 0.05 Pain Relevance 0
The initial banding procedure did not alter heifer physiology and altered only eating behavior, but the cutting of the tail (docking) increased haptoglobin in response to the tissue damage and returned eating behavior to baseline.
Positive_regulation (increased) of haptoglobin in tail
5) Confidence 0.36 Published 2000 Journal J. Dairy Sci. Section Abstract Doc Link 10908053 Disease Relevance 0.15 Pain Relevance 0.31
Laboratory evaluation showed hemolytic anemia with fragmentation, thrombocytopenia, elevated lactic dehydrogenase level, low haptoglobin level, low complement C3 level, and elevated antistreptolysin-O titer.
Positive_regulation (elevated) of haptoglobin associated with hemolytic anemia and thrombocytopenia
6) Confidence 0.36 Published 2005 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16183409 Disease Relevance 1.56 Pain Relevance 0.09
RESULTS: The mulesed lambs exhibited large increases in plasma concentrations of cortisol, beta-endorphin and haptoglobin.
Positive_regulation (increases) of haptoglobin in plasma
7) Confidence 0.36 Published 2008 Journal Aust. Vet. J. Section Body Doc Link 18673471 Disease Relevance 0.20 Pain Relevance 0
Haptoglobin increased for docked heifers by 168 h postbanding (24 h postdocking).
Positive_regulation (increased) of Haptoglobin
8) Confidence 0.21 Published 2000 Journal J. Dairy Sci. Section Abstract Doc Link 10908053 Disease Relevance 0.17 Pain Relevance 0.24
Apolipoprotein A-I forms have decreased spot volumes, while haptoglobin alpha1, in contrast, was elevated in several tumors.
Positive_regulation (elevated) of haptoglobin associated with cancer and disorder of lipid metabolism
9) Confidence 0.14 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.20 Pain Relevance 0
Rather than cause cardiovascular events, elevated BP may be the consequence of changes in the heart and vasculature that overlap those that lead to cardiovascular events (Figure 1).
Positive_regulation (elevated) of BP in vasculature
10) Confidence 0.11 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.49 Pain Relevance 0
This assumption may not, however, be correct, except in extreme situations such as flash pulmonary edema due to acute severe elevation of BP.
Positive_regulation (elevation) of BP associated with heart rate under development
11) Confidence 0.11 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.50 Pain Relevance 0
Of the 35 women with GI lesions, 47% were diagnosed with H. pylori (Hp) gastritis and 17% with celiac disease, with the authors recommending routine use of the urea breath test and celiac serologies in their population, with endoscopic evaluation reserved only for those who test negative for Hp or celiac disease or whose IDA fails to resolve after Hp eradication [47].
Positive_regulation (negative) of Hp associated with celiac disease, iron-deficiency anemia and gastritis
12) Confidence 0.09 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.27 Pain Relevance 0.10
In subjects with prehypertension, the differences in systolic BP and diastolic BP between MPH1 and placebo were not significant.
Positive_regulation (diastolic) of BP associated with prehypertension and hypertension
13) Confidence 0.08 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 1.20 Pain Relevance 0
Over twenty five human studies have been performed linking the consumption of products containing both IPP and VPP with significant reductions in BP [4-6].
Positive_regulation (reductions) of BP associated with hypertension
14) Confidence 0.08 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 0.52 Pain Relevance 0
Cohort studies of sorafenib (17) and sunitinib (3) detected elevations in BP for the population during the first cycle of treatment.
Positive_regulation (elevations) of BP
15) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.52 Pain Relevance 0
Proper agent selection, dosing, and scheduling of follow-up should enable maintaining VSP inhibition while avoiding the complications associated with excessive or prolonged elevation in BP.



Positive_regulation (elevation) of BP
16) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Abstract Doc Link PMC2864290 Disease Relevance 0.27 Pain Relevance 0
Some patients had no elevation in BP, and others had increases in diastolic BP greater than 20 mmHg.
Neg (no) Positive_regulation (elevation) of BP
17) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.06 Pain Relevance 0
Some patients had no elevation in BP, and others had increases in diastolic BP greater than 20 mmHg.
Positive_regulation (increases) of BP
18) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.06 Pain Relevance 0
Nevertheless, control of BP is important for patients receiving VSP inhibitor therapy for the following five reasons:Serious adverse events have been associated with unmanaged hypertension (1–3,5,34), and these could be prevented with control of BP before and early in the course of VSP inhibitor therapy.These agents can cause dramatic increases in BP from pretreatment measurements (as high as 29 mmHg systolic and 27 mmHg diastolic in one prospective clinical investigation) (35) during the first week of treatment (35,36), and currently, it cannot be predicted which patients will have this magnitude of BP elevation.Although minimalist approaches to hypertension for patients with incurable disease might be favored in certain circumstances, management of comorbidities, including hypertension, could improve overall survival.
Positive_regulation (increases) of BP associated with hypertension and disease
19) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.70 Pain Relevance 0
Excessive alcohol consumption and some agents that are commonly prescribed by oncologists also elevate BP, including nonsteroidal anti-inflammatory drugs (including cyclooxygenase 2 inhibitors), adrenal steroid hormones, erythropoietin, oral contraceptive hormones, and sympathomimetics, such as methylphenidate.
Positive_regulation (elevate) of BP associated with inflammation, cinod, cox2 and alcohol
20) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.33 Pain Relevance 0.20

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