INT180442

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acot1, Rhoa) cytoplasm (Acot1, Rhoa) cytosol (Acot1, Rhoa)
cell differentiation (Rhoa) cell morphogenesis (Rhoa) intracellular (Rhoa)
Acot1 (Mus musculus)
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 16 97.24 Very High Very High Very High
cytokine 2 87.00 High High
Inflammation 2 86.60 High High
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 16 91.28 High High
Necrosis 2 87.92 High High
Cancer 2 87.56 High High
INFLAMMATION 2 86.60 High High
Hypersensitivity 4 86.48 High High
Occupational Lung Diseases 4 85.76 High High
Hypertension 4 55.68 Quite High
Coronary Vasospasm 2 53.76 Quite High
Myocardial Infarction 2 49.36 Quite Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with our current findings, it is likely that the enhanced contractility to agonists reflects, at least in part, the augmentation of muscarinic receptor- and RhoA-mediated Ca2+ sensitization, although the mechanism(s) for activation of RhoA by ACh is still unclear.
ACh Positive_regulation (activation) of RhoA associated with agonist
1) Confidence 0.08 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.59 Pain Relevance 0.19
It is thus likely that ACh stimulation activates the upregulated RhoA (Fig. 5), resulting in a greater phosphorylation of MLC (Fig. 6) and contraction of BSMs in AHR mice.
ACh Positive_regulation (activates) of RhoA
2) Confidence 0.08 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.43 Pain Relevance 0.19

General Comments

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