INT180739

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 7.88
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACE2) extracellular space (ACE2) extracellular region (ACE2)
plasma membrane (ACE2)
Anatomy Link Frequency
lung 2
smooth muscle cells 1
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 99.16 Very High Very High Very High
ischemia 59 81.56 Quite High
Angina 10 57.64 Quite High
headache 8 55.84 Quite High
antagonist 9 55.76 Quite High
Bioavailability 1 52.60 Quite High
metalloproteinase 6 45.68 Quite Low
corticosteroid 10 32.48 Quite Low
Pain 3 20.68 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 231 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 44 100.00 Very High Very High Very High
Pressure And Volume Under Development 7 99.56 Very High Very High Very High
Chromosome Aberrations 1 99.24 Very High Very High Very High
INFLAMMATION 27 99.16 Very High Very High Very High
Disease 153 96.36 Very High Very High Very High
Infection 82 91.44 High High
Influenza Virus Infection 44 85.68 High High
Respiratory Syncytial Virus 38 85.12 High High
Atherosclerosis 17 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum ACE2 activity in vasculopathy patients, control patients, and healthy subjects
ACE2 Binding (activity) of
1) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.22 Pain Relevance 0.04
Measurement of serum ACE2 activity
ACE2 Binding (activity) of
2) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0 Pain Relevance 0
Sera from 17 of the 18 (94%) vasculopathy patients showed reactivity to ACE2 with ELISA values above the baseline level value, which was determined as the mean ELISA score in the 28 normal control subjects.
ACE2 Binding (reactivity) of
3) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 1.56 Pain Relevance 0.06
Also, antibodies against ACE2, but not inhibitors binding to the active site of ACE2 may be useful for the development of therapeutic strategies.


ACE2 Binding (binding) of
4) Confidence 0.17 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 0.76 Pain Relevance 0
ACE-2 has a key protective role in acute lung injury by reducing alveolar fluid, and thus the binding of SARS-CoV to ACE-2 may contribute to the dysregulation of fluid balance in the alveolar space [48].
ACE-2 Binding (binding) of in lung associated with severe acute respiratory syndrome and adult respiratory distress syndrome
5) Confidence 0.11 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 2.02 Pain Relevance 0.10
ACE-2 has a key protective role in acute lung injury by reducing alveolar fluid, and thus the binding of SARS-CoV to ACE-2 may contribute to the dysregulation of fluid balance in the alveolar space [48].
ACE-2 Binding (binding) of in lung associated with severe acute respiratory syndrome and adult respiratory distress syndrome
6) Confidence 0.11 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 2.07 Pain Relevance 0.11
PAPP-A is a zinc-binding metalloprotease that indirectly activates insuline-like growth factor (IGF), a potent mitogen and chemotactic agent for vascular smooth muscle cells.
metalloprotease Binding (binding) of in smooth muscle cells
7) Confidence 0.02 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.25 Pain Relevance 0.14

General Comments

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