INT180787

Context Info Confidence 0.18 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.28 Pain Relevance 0.95

extracellular space (Calca, Gdnf) extracellular region (Calca, Gdnf) cell proliferation (Gdnf) aging (Calca) nucleus (Calca) intracellular (Calca)

Anatomy Link Frequency neurons 1 Calca (Rattus norvegicus) Gdnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 96 100.00 qutenza 52 100.00 Neuropeptide 11 100.00 Nerve growth factor 100 99.60 trigeminal ganglion 59 75.20 Inflammation 6 74.96 Trigeminal ganglion neurons 1 50.00 Hyperalgesia 3 39.44 Pain 3 20.08 dorsal root ganglion 12 14.52

Disease Link Frequency Relevance Heat Ganglion Cysts 73 75.20 INFLAMMATION 5 74.96 Hyperalgesia 7 39.44 Pain 3 20.08 Injury 23 6.24 Nociception 8 5.00 Headache 6 5.00 Apoptosis 2 5.00 Nervous System Injury 2 5.00 Disease 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After normalization to the number of neurons that express TRPV1 and CGRP, we found that NGF had a much greater effect on CAP-evoked CGRP release and neuropeptide content, on a per cell basis, than did GDNF.

CGRP release Regulation (effect) of GDNF in neurons associated with qutenza, nerve growth factor, neuropeptide and calcitonin gene-related peptide

1) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.28 Pain Relevance 0.95

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