INT180964

Context Info Confidence 0.24 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.45 Pain Relevance 0.25

peptidase activity (PLG, MMP13) extracellular space (PLG, MMP13) extracellular region (PLG, MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) plasma membrane (PLG)

PLG (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 46 99.60 Spinal cord 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 59 97.48 Cancer 18 25.44 Hypercalcemia 7 5.00 Osteoporosis 6 5.00 Metastasis 3 5.00 Osteolysis 2 5.00 Reprotox - General 1 1 5.00 Pain 1 5.00 Disease 1 5.00 Skin Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The activation of MMP-13 in human breast cancer cells was prevented by plasminogen activator inhibitor-1 but not by tissue inhibitor of metalloproteinase-1, suggesting that plasmin activates MMP-13 directly.

plasmin Positive_regulation (activates) of MMP-13 associated with breast cancer and metalloproteinase

1) Confidence 0.24 Published 2005 Journal Cancer Cell Int Section Abstract Doc Link PMC548674 Disease Relevance 0.45 Pain Relevance 0.25

General Comments

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