INT180966

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.55
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
cartilage 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 187 99.76 Very High Very High Very High
Osteoarthritis 35 97.96 Very High Very High Very High
Pain 5 49.12 Quite Low
rheumatoid arthritis 3 44.88 Quite Low
Inflammation 63 39.84 Quite Low
Nicotine 20 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
transdermal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 236 99.98 Very High Very High Very High
Cancer 94 99.24 Very High Very High Very High
Osteoarthritis 36 97.96 Very High Very High Very High
Metastasis 20 96.24 Very High Very High Very High
Skin Cancer 6 93.52 High High
Osteoporosis 25 80.56 Quite High
Carcinoma 6 75.16 Quite High
Nicotine Addiction 366 69.60 Quite High
Adhesions 186 50.00 Quite Low
Increased Venous Pressure Under Development 32 49.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data presented in this paper clearly demonstrate that human breast carcinoma cell lines have the capacity to degrade the organic aspect of bone matrix in vitro, and there is a dependency on the PA system for the cell-mediated collagen degradation.
Positive_regulation (mediated) of Protein_catabolism (degradation) of collagen associated with breast cancer
1) Confidence 0.06 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.37 Pain Relevance 0.04
Interestingly, the depletion of plasminogen from serum also completely blocked breast cancer cell mediated collagen dissolution, implicating the PAS in breast cancer-mediated collagen degradation (Fig. 1).
Positive_regulation (mediated) of Protein_catabolism (degradation) of collagen associated with breast cancer
2) Confidence 0.05 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.67 Pain Relevance 0.03
-stimulated breast cancer cell mediated bone collagen degradation (Fig. 6).
Positive_regulation (mediated) of Protein_catabolism (degradation) of collagen associated with breast cancer
3) Confidence 0.04 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.57 Pain Relevance 0.12
Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity

Background

Positive_regulation (mediated) of Protein_catabolism (degradation) of collagen associated with breast cancer and metalloproteinase
4) Confidence 0.04 Published 2005 Journal Cancer Cell Int Section Title Doc Link PMC548674 Disease Relevance 0.58 Pain Relevance 0.14
In OA cartilage, ET-1 is involved in cartilage catabolism through metalloprotease (MMP) regulation and the induction of type II collagen breakdown [2].
Positive_regulation (induction) of Protein_catabolism (breakdown) of collagen in cartilage associated with osteoarthritis
5) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.19 Pain Relevance 0.10
Interestingly, CD44 may act as a tumor cell surface anchor for MMP-9, a matrix metalloproteinase, which may contribute to collagen degradation and contribute to tumor invasiveness [60]. sCD44 can disrupt CD44/MMP-9 clusters and inhibit tumor metastasis in vivo [60].
Positive_regulation (contribute) of Protein_catabolism (degradation) of collagen associated with cancer, metalloproteinase and metastasis
6) Confidence 0.02 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.08 Pain Relevance 0.05
Interestingly, CD44 may act as a tumor cell surface anchor for MMP-9, a matrix metalloproteinase, which may contribute to collagen degradation and contribute to tumor invasiveness [60]. sCD44 can disrupt CD44/MMP-9 clusters and inhibit tumor metastasis in vivo [60].
Positive_regulation (contribute) of Protein_catabolism (degradation) of collagen associated with cancer, metalloproteinase and metastasis
7) Confidence 0.02 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.08 Pain Relevance 0.05

General Comments

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