INT181008

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.32
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
THP-1 6
corneal epithelial cell 2
microglial cells 2
neutrophils 2
mononuclear cells 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 206 100.00 Very High Very High Very High
Morphine 206 99.98 Very High Very High Very High
corticosteroid 2 99.84 Very High Very High Very High
sodium channel 5 99.52 Very High Very High Very High
dexamethasone 87 99.00 Very High Very High Very High
Inflammatory response 22 96.16 Very High Very High Very High
Inflammation 188 95.68 Very High Very High Very High
withdrawal 18 91.20 High High
Hyperalgesia 21 87.12 High High
tetrodotoxin 1 75.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 225 95.76 Very High Very High Very High
Systemic Inflammatory Response Syndrome 7 95.04 Very High Very High Very High
Infection 43 94.52 High High
Sepsis 51 89.60 High High
Hyperalgesia 33 87.12 High High
Hyperplasia 1 85.28 High High
Osteoarthritis 126 82.72 Quite High
Pain 40 75.00 Quite High
Necrosis 12 70.08 Quite High
Cancer 14 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In earlier work, we showed that LPS-induced secretion of cytokines could be blocked by corticosteroids like dexamethasone [16].


Negative_regulation (blocked) of Localization (secretion) of LPS associated with corticosteroid, dexamethasone and cytokine
1) Confidence 0.14 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.27 Pain Relevance 0.33
Inhibition of LPS-induced cytokine release by Prolastin was concentration-dependent and was typically observed over a concentration range of 0.5–16 mg/ml.
Negative_regulation (Inhibition) of Localization (release) of LPS associated with cytokine
2) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.09
In addition, our results indicated that low concentrations of morphine inhibit LPS-induced IL-8 secretion by neutrophils.
Negative_regulation (inhibit) of Localization (secretion) of LPS in neutrophils associated with morphine
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.72 Pain Relevance 0.83
BOL-303242-X reduces LPS-induced cytokine release in THP-1 cells
Negative_regulation (reduces) of Localization (release) of LPS in THP-1 associated with cytokine
4) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.25 Pain Relevance 0.51
BOL-303242-X demonstrates activity similar to classical glucocorticoids in inhibiting LPS- or IL-1ß-induced cytokine release in four different primary human ocular cells
Negative_regulation (inhibiting) of Localization (release) of LPS associated with cytokine
5) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0 Pain Relevance 0.24
An early study from Song et al. [16] showed a clear LPS-stimulated, CD14 antibody-inhibited IL-6 and IL-8 secretion in a human corneal epithelial cell line.
Negative_regulation (inhibited) of Localization (secretion) of LPS in corneal epithelial cell
6) Confidence 0.09 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.15 Pain Relevance 0.11
g/ml LPS: 12.8 rMFI vs. 16.1 rMFI after 1 ?
Negative_regulation (12.8) of Localization (rMFI) of LPS
7) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0 Pain Relevance 0
g/ml LPS: 12.8 rMFI vs. 16.1 rMFI after 1 ?
Negative_regulation (rMFI) of Localization (rMFI) of LPS
8) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0 Pain Relevance 0
g/ml LPS: 12.8 rMFI vs. 16.1 rMFI after 1 ?
Negative_regulation (after) of Localization (rMFI) of LPS
9) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0 Pain Relevance 0
In microglial cells, blockade of sodium channels with PHT significantly reduced LPS-induced secretion of IL-1?
Negative_regulation (reduced) of Localization (secretion) of LPS in microglial cells associated with sodium channel
10) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0.29
Similarly, SB-203580 and VX-745 potently inhibited TNF release from LPS stimulated human THP-1 cells with IC50s of 72 ± 15 nM; and 29 ± 14 nM (mean ± S.D.) respectively.
Negative_regulation (inhibited) of Localization (release) of LPS in THP-1
11) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2612656 Disease Relevance 0.64 Pain Relevance 0.35
Similarly, SB-203580 and VX-745 potently inhibited TNF release from LPS stimulated human THP-1 cells with IC50's of 72 ± 15 nM; (mean ± S.D., n = 65) and 29 ± 14 nM; (mean ± S.D., n = 3) respectively.
Negative_regulation (inhibited) of Localization (release) of LPS in THP-1
12) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 0.12 Pain Relevance 0.13
TNF release from LPS stimulated human peripheral blood mononuclear cells was inhibited with IC50s 16 ± 6 nM and 14 ± 8 nM, (mean ± S.D., n = 3) for SB-203580 and VX-745 and IL-1 was inhibited with IC50s of 20 ± 8 nM and 15 ± 4 nM (mean ± S.D., n = 3), respectively (Table 1).


Negative_regulation (inhibited) of Localization (release) of LPS in mononuclear cells
13) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 0.08 Pain Relevance 0.07

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