INT181244

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 0.56
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ZBTB32) nuclear chromosome (ZBTB32) nucleus (ZBTB32)
intracellular (ZBTB32) DNA binding (ZBTB32)
ZBTB32 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 83 100.00 Very High Very High Very High
Kappa opioid receptor 456 99.44 Very High Very High Very High
antagonist 171 99.30 Very High Very High Very High
agonist 456 99.20 Very High Very High Very High
Potency 38 91.16 High High
opioid receptor 95 84.28 Quite High
addiction 57 82.96 Quite High
tolerance 57 82.40 Quite High
mu opioid receptor 323 81.40 Quite High
Opioid 76 79.00 Quite High
Disease Link Frequency Relevance Heat
Depression 105 100.00 Very High Very High Very High
Stress 2 44.92 Quite Low
Anxiety Disorder 6 44.24 Quite Low
Nicotine Addiction 1 32.16 Quite Low
Drug Dependence 1 29.76 Quite Low
Targeted Disruption 38 18.52 Low Low
Coronary Heart Disease 38 17.44 Low Low
Myocardial Infarction 20 14.84 Low Low
Death 3 13.84 Low Low
Suicidal Behaviour 4 12.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Men felt that depression or chinta rog was more common among men whereas women felt that it was the women who mostly suffered from it.
Gene_expression (depression) of rog associated with depression
1) Confidence 0.59 Published 2010 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2975851 Disease Relevance 0.56 Pain Relevance 0.28
Rog was transiently transfected into CHO cells along with a chimeric Gqi5 protein [20] that couples to Gi-coupled receptors but signals through the Gq pathway and therefore stimulates calcium release.
Gene_expression (transfected) of Rog
2) Confidence 0.51 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.37
The increase in membrane expression of Rog-?
Gene_expression (expression) of Rog
3) Confidence 0.51 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.25
Notably, cells expressing Rog-?
Gene_expression (expressing) of Rog
4) Confidence 0.44 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.12
Therefore, the same mutations that prolong Rog-A signaling and inhibit endocytosis may also prevent the receptor from interacting with GRK2/3 proteins and subsequently activating G??
Gene_expression (prolong) of Rog
5) Confidence 0.44 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0
This would suggest that in the absence of norBNI, Rog-?
Neg (absence) Gene_expression (absence) of Rog
6) Confidence 0.44 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.29
The observation that the addition of an antagonist can "rescue" the low cell-surface expression of Rog-?
Gene_expression (expression) of Rog associated with antagonist
7) Confidence 0.44 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.54
HEK293 cells stably transfected with Rog-A were treated with 10 ?
Gene_expression (transfected) of Rog
8) Confidence 0.44 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.15
It also increased the cell-surface expression of Rog-?
Gene_expression (expression) of Rog
9) Confidence 0.39 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.26
As shown by cell-surface ELISA of one representative group of stably transfected HEK293 lines, Rog-?
Gene_expression (transfected) of Rog
10) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.19
Rog, a GFP-tagged RASSL, signals appropriately
Gene_expression (signals) of Rog
11) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.35
, while Rog-?
Gene_expression (while) of Rog
12) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.31
Notably, the maximal response of pretreated Rog-?
Gene_expression (response) of Rog
13) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.03
A was expressed at 28% of the level of Rog, and 41% of Rog-?
Gene_expression (expressed) of Rog
14) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.19
M norBNI, most of the Rog-?
Gene_expression (most) of Rog
15) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.22
As observed with Rog, maximal internalization of Rog-A in response to 1 ?
Gene_expression (observed) of Rog
16) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.09
A was expressed at 28% of the level of Rog, and 41% of Rog-?
Gene_expression (expressed) of Rog
17) Confidence 0.38 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.20
Despite the low cell-surface expression, Rog-?
Gene_expression (expression) of Rog
18) Confidence 0.34 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.23
Overnight treatment of Rog-A-expressing cells with spiradoline, followed by stimulation with 10 ?
Gene_expression (expressing) of Rog
19) Confidence 0.34 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.13
M) stimulates twice as much cAMP in Rog-expressing cells treated with 10 nM spiradoline for 18 hours, compared to cells acutely treated with forskolin alone (Figure 5B; p < 0.005, F1,10 = 17.72).
Gene_expression (expressing) of Rog
20) Confidence 0.34 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.12

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