INT181344

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 28
Total Number 35
Disease Relevance 24.34
Pain Relevance 9.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr6) plasma membrane (Ccr6) signal transducer activity (Ccr6)
Anatomy Link Frequency
T cells 8
Th17 cells 5
colon 1
lymphocytes 1
dendritic cells 1
Ccr6 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 502 99.68 Very High Very High Very High
chemokine 316 99.50 Very High Very High Very High
Crohn's disease 371 99.28 Very High Very High Very High
Inflammation 532 98.94 Very High Very High Very High
rheumatoid arthritis 508 98.24 Very High Very High Very High
Arthritis 613 97.22 Very High Very High Very High
cytokine 539 95.00 High High
Inflammatory mediators 15 94.68 High High
Spinal cord 56 93.68 High High
Multiple sclerosis 372 77.48 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 378 99.92 Very High Very High Very High
Multiple Sclerosis 1086 99.84 Very High Very High Very High
Central Nervous System Disease 480 99.68 Very High Very High Very High
Disease 732 99.28 Very High Very High Very High
INFLAMMATION 510 98.94 Very High Very High Very High
Rheumatoid Arthritis 509 98.24 Very High Very High Very High
Experimental Arthritis 49 97.22 Very High Very High Very High
Autoimmune Disease 156 96.08 Very High Very High Very High
Death 67 90.44 High High
Viral Meningitis 7 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, we found that 1,25(OH)2D3 inhibited the expression of CCR6 on T cells that had been activated by both TGF-?
Gene_expression (expression) of CCR6 in T cells
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.76 Pain Relevance 0.28
Most importantly, 1,25(OH)2D3 negatively regulates the expression of CCR6 on the TH17 cells.
Gene_expression (expression) of CCR6
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.47 Pain Relevance 0.12
The VDR signal on the CD4+ T cells inhibits the expression of IL-17, IL-2, Foxp3, and CCR6 but enhances the expression of IL-10.
Gene_expression (expression) of CCR6 in T cells
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.38 Pain Relevance 0.09
Our data suggest the possibility that VDR activation modulates CCR6 expression and leads to a functional hypo-responsiveness to CCL20.
Gene_expression (expression) of CCR6
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.48 Pain Relevance 0.11
Overall, we found that vitamin D3 down-regulates CCR6 but not CCR10 expression in the TH17-conditioned circumstance.
Gene_expression (expression) of CCR6
5) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.44 Pain Relevance 0.13
Since one recent study also showed that vitamin D3 induces the expression of CCR10 on activated CD4+ T cells in the presence of IL-12 [57], we investigated the possibility that vitamin D3 also plays a role in the ability of TH17 cells to express CCR10 instead of CCR6.
Gene_expression (express) of CCR6 in T cells
6) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.53 Pain Relevance 0.24
Expression levels of both CCR6 (UC, P = 0.0004; CD, P = 0.011) and CCL20 (UC; P = 0.0003, CD; P = 0.0009) were significantly increased in colonic CD and UC samples but not in ileal CD samples (Figure 2D).


Gene_expression (Expression) of CCR6 associated with inflammatory bowel disease and crohn's disease
7) Confidence 0.61 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 2.22 Pain Relevance 0.56
To investigate the direct effect of vitamin D3 on the migration of TH17 cells into the CNS, we analyzed the CCR6 expression of the OVA-specific CD4+ T cells under TH17-polarizing conditions.
Spec (analyzed) Gene_expression (expression) of CCR6 in T cells associated with central nervous system
8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.45 Pain Relevance 0.14
We further checked the expression levels of CCR6 in an EAE-relevant T cell system.
Gene_expression (expression) of CCR6 in T cell associated with multiple sclerosis
9) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.44 Pain Relevance 0.13
Interestingly, 1,25(OH)2D3 reduced the expression of CCR6 on activated MOG-specific CD4+ T cells (data not shown).
Gene_expression (expression) of CCR6 in T cells
10) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.42 Pain Relevance 0.12
Chemokine (C-C motif) receptor 6 (CCR6) which is expressed on the surface of Th17 cells, contributes to their recruitment to chemokine (C-C motif) ligand 20 (CCL20) produced at the inflamed mucosa [21].
Gene_expression (expressed) of CCR6 in Th17 cells associated with chemokine
11) Confidence 0.53 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.39 Pain Relevance 0.27
Further, TH17 cells predominantly express CCR6 [56].
Gene_expression (express) of CCR6
12) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.88 Pain Relevance 0.20
To further address the regulation of CCR6 expression by 1,25(OH)2D3, we evaluated the migratory characteristics of TH17 cells generated in vitro using the Transwell chemotaxis assay.
Gene_expression (expression) of CCR6
13) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.45 Pain Relevance 0.14
Our findings establish that oral treatment with systemic 1,25(OH)2D3 directly modulates to T cells to prevent both the development of TH17 cells and the expression of CCR6 in EAE-induced conditions.
Gene_expression (expression) of CCR6 in T cells associated with multiple sclerosis
14) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.62 Pain Relevance 0.05
Importantly, 1,25(OH)2D3 regulates the migration of TH17 cells into the CNS by suppressing CCR6 expression.
Gene_expression (expression) of CCR6 associated with central nervous system
15) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.45 Pain Relevance 0.05
These results suggest that vitamin D3 inhibits the CCR6 expression on TH17 cells, which may block TH17 cells from entering the CNS.


Gene_expression (expression) of CCR6 associated with central nervous system
16) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.56 Pain Relevance 0.18
A recent study found that CCR6 plays an essential role in the initiation of EAE and that CCL20, a CCR6 ligand, is constitutively expressed in choroid plexus epithelial cells in mice and humans [44].
Gene_expression (expressed) of CCR6 in choroid plexus epithelial cells associated with multiple sclerosis
17) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.87 Pain Relevance 0.16
Of note, consistent with the suppression of CCR6 expression by 1,25(OH)2D3, 1,25(OH)2D3-treated TH17 cells migrated, to a much lesser degree, toward MIP-3?
Gene_expression (expression) of CCR6
18) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.55 Pain Relevance 0.17
Evaluation of mRNA expression levels in colonic and ileal control samples revealed that TNF, TGFB1, STAT3 and CCR6 were expressed at higher levels in the ileum than in the colon.
Gene_expression (expressed) of CCR6 in colon
19) Confidence 0.47 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.99 Pain Relevance 0.37
Although increased expression of IL17A, IL17F, IL21 and IL26 was detected in inflamed ileal samples, expression of the indispensable Th17 cell differentiation factors TGFB1 and IL23A, the signaling molecule STAT3 and the Th17 recruitment factors CCR6 and CCL20 were unchanged.


Gene_expression (expression) of CCR6 in Th17 cell
20) Confidence 0.47 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.81 Pain Relevance 0.32

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