INT181354

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.94
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr7) plasma membrane (Ccr7) intracellular (Ccr7)
signal transducer activity (Ccr7)
Anatomy Link Frequency
lymph nodes 1
T-cell 1
mononuclear cells 1
Ccr7 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 100 99.60 Very High Very High Very High
Inflammation 87 95.44 Very High Very High Very High
Central nervous system 50 92.56 High High
cytokine 81 84.60 Quite High
chemokine 124 80.20 Quite High
antagonist 8 61.44 Quite High
Multiple sclerosis 60 52.56 Quite High
Demyelination 12 11.52 Low Low
abatacept 8 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 100 99.60 Very High Very High Very High
Adhesions 13 96.80 Very High Very High Very High
INFLAMMATION 89 95.44 Very High Very High Very High
Central Nervous System Disease 48 92.56 High High
Multiple Sclerosis 79 91.56 High High
Disease 41 58.32 Quite High
Autoimmune Disease 3 54.32 Quite High
Demyelinating Disease 78 52.56 Quite High
Recurrence 16 47.80 Quite Low
Immunization 5 34.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experimental evidence now suggests that CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8 and CXCR3 on hematogenous mononuclear cells recognize these chemoattractant and regulatory molecules to induce cell differentiation, adhesion or migration of distinct inflammatory cells in peripheral lymphoid organs, at the BBB and in the CNS during the course of EAE.
CCR7 Binding (recognize) of in mononuclear cells associated with multiple sclerosis, inflammation, central nervous system and adhesions
1) Confidence 0.23 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.99 Pain Relevance 0.27
Conversely, CCL19, CCL21 and their associated receptor CCR7 contribute to the accumulation of mature DCs in T-cell-rich areas of lymphoid organs and to the formation of germinal centres [31].
CCR7 Binding (associated) of in T-cell
2) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.54 Pain Relevance 0.45
As opposed to the situation in lymph nodes, CCL19 and CCL21, which control the migration of mature DCs, were rarely expressed in RA synovium and their associated receptor CCR7 was poorly expressed [32].
CCR7 Binding (associated) of in lymph nodes associated with rheumatoid arthritis
3) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.41 Pain Relevance 0.29

General Comments

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