INT181406

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 17.00
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
macrophages 2
eosinophils 1
basophils 1
memory T-cells 1
monocytes 1
Ccr5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 779 99.78 Very High Very High Very High
Multiple sclerosis 360 99.66 Very High Very High Very High
Inflammation 409 96.88 Very High Very High Very High
Inflammatory response 29 95.24 Very High Very High Very High
Central nervous system 300 92.56 High High
antagonist 143 88.76 High High
Demyelination 72 88.40 High High
potassium channel 8 87.84 High High
rheumatoid arthritis 6 69.52 Quite High
cytokine 125 58.76 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 237 99.80 Very High Very High Very High
Demyelinating Disease 468 99.66 Very High Very High Very High
Recurrence 96 98.70 Very High Very High Very High
Death 15 98.00 Very High Very High Very High
INFLAMMATION 427 96.88 Very High Very High Very High
Adhesions 77 96.80 Very High Very High Very High
Disease 177 94.52 High High
Infection 354 94.48 High High
Pulmonary Disease 107 94.32 High High
Central Nervous System Disease 288 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The bridging sheet interacts with the N-terminus of CCR5 or CXCR4.
CCR5 Binding (interacts) of
1) Confidence 0.45 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.48 Pain Relevance 0.12
For example, TNX-355 targets CD4, PRO 542 is aimed at gp120, and PRO 140 and HGS004 bind CCR5.
CCR5 Binding (bind) of
2) Confidence 0.35 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.25 Pain Relevance 0.03
The V3 loop, on the other hand, mediates interactions with the second extracellular loop (ECL2) of CCR5 or CXCR4 and is the principle determinant of coreceptor specificity.
CCR5 Spec (determinant) Binding (interactions) of
3) Confidence 0.35 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.45 Pain Relevance 0.11
A recent review of chemokines and their receptors [39] suggests that every CC chemokine receptor (CCR1-CCR5) interact with multiple CCLs and vice versa.
CCR1-CCR5 Binding (interact) of associated with chemokine
4) Confidence 0.34 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.13 Pain Relevance 0.51
The CCL3 and CCR5 interaction promotes polarization towards the TH1 subtype.
CCR5 Binding (interaction) of
5) Confidence 0.34 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.79 Pain Relevance 0.46
Insertion of these small molecules into a cavity located within the transmembrane helices disrupts the geometry of a multi-point interaction between CCR5 and HIV-1 gp120 (Dragic et al 2000; Tsamis et al 2003; Watson et al 2005; Seibert et al 2006).
CCR5 Binding (interaction) of in cavity associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.34 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.27 Pain Relevance 0.14
The pattern of CCL5 and CCR5 as well as IFN-?
CCR5 Binding (pattern) of
7) Confidence 0.33 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.96 Pain Relevance 0.15
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of in macrophages
8) Confidence 0.29 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
Experimental evidence now suggests that CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8 and CXCR3 on hematogenous mononuclear cells recognize these chemoattractant and regulatory molecules to induce cell differentiation, adhesion or migration of distinct inflammatory cells in peripheral lymphoid organs, at the BBB and in the CNS during the course of EAE.
CCR5 Binding (recognize) of in mononuclear cells associated with multiple sclerosis, inflammation, central nervous system and adhesions
9) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.04 Pain Relevance 0.27
32 deletion) have prolonged relapse free periods, but the long term prognosis of MS did not seem to correlate with the CCR5 ?
CCR5 Binding (correlate) of associated with multiple sclerosis and recurrence
10) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.63 Pain Relevance 0.27
In later stages, macrophages became CCR1-/CCR5+, while microglia upregulated CCR5.
CCR5 Binding (macrophages) of in macrophages
11) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.75 Pain Relevance 0.28
Further, the complexity of information regarding CCR5 is reflected by a recent study suggesting the association of the CCR5 ?
CCR5 Binding (association) of
12) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.78 Pain Relevance 0.40
or CCL4), interacting with their CCR5 receptor.
CCR5 Binding (receptor) of
13) Confidence 0.12 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.93 Pain Relevance 0.45
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of in eosinophils
14) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of in endothelial cells
15) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of in mast cells
16) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of in monocytes
17) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of in memory T-cells
18) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of in basophils
19) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37

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