INT181526

Context Info Confidence 0.49 First Reported 2005 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 13 Disease Relevance 4.09 Pain Relevance 1.30

extracellular space (Apcs) extracellular region (Apcs) protein complex assembly (Apcs) protein complex (Apcs)

Anatomy Link Frequency T cells 2 CD86 1 neuron 1 spleen 1 body 1 Apcs (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 135 99.60 Inflammation 91 98.44 agonist 30 91.84 Glutamate 7 91.64 tolerance 24 76.28 Arthritis 27 74.56 Somatosensory cortex 42 74.08 Action potential 12 70.80 antagonist 1 66.96 rheumatoid arthritis 33 66.32

Disease Link Frequency Relevance Heat Alzheimer's Dementia 2 100.00 INFLAMMATION 113 98.44 Lymphopenia 18 98.40 Autoimmune Disease 46 95.76 Immunization 100 93.76 Synovitis 38 91.92 Arthritis 27 74.56 Infection 59 70.24 Candida Infection 48 70.16 Rheumatoid Arthritis 33 66.32

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-/- mice is less likely to be mediated by lack of upregulation of costimulatory molecules on APCs as we have previously reported that these mice have upregulated B7.1/2 on APCs[19].

Positive_regulation (upregulation) of APCs

1) Confidence 0.49 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.46 Pain Relevance 0.10

It was also shown that CpG stimulate T cells by inducing APCs to synthesize IFN-I, which then act directly on T cells via IFNAR[37].

Positive_regulation (inducing) of APCs in T cells

2) Confidence 0.40 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.05 Pain Relevance 0.03

-/- mice is less likely to be mediated by lack of upregulation of costimulatory molecules on APCs as we have previously reported that these mice have upregulated B7.1/2 on APCs[19].

Positive_regulation (upregulated) of APCs

3) Confidence 0.33 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.56 Pain Relevance 0.11

-/- mice is less likely to be mediated by lack of upregulation of costimulatory molecules on APCs as we have previously reported that these mice have upregulated B7.1/2 on APCs[19].

Positive_regulation (upregulation) of APCs

4) Confidence 0.33 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.56 Pain Relevance 0.11

Second, total body irradiation as well as the absence of Tregs may result in the generalized activation of APCs [15], [16].

Positive_regulation (activation) of APCs in body

5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.79 Pain Relevance 0.14

LPS, major outer membrane constituent of Gram-negative bacteria, stimulates APCs through TLR4, induces high levels of pro-inflammatory cytokines and usually leads to a strong Th1 response (38).

Positive_regulation (stimulates) of APCs associated with inflammation and cytokine

6) Confidence 0.22 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.42 Pain Relevance 0.10

Activation of TLRs is necessary for optimal activation of APCs to initiate and polarize adaptive immune responses against invading pathogens [56,57].

Positive_regulation (activation) of APCs

7) Confidence 0.18 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.08

The increase in VSV-specific CD8+ cells observed with VV-hTAP1,2 coinfections indicates a TAP-dependent increase in APC cross-priming and cross-presentation activity and is explained by an increase in TAP expression and peptide-transport activity in the APCs of the spleen.

Positive_regulation (increase) of APCs in spleen

8) Confidence 0.17 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.07 Pain Relevance 0

More appropriately, the pathway is now recognized as a mechanism to activate APCs and to enhance their potential to activate T cells.

Positive_regulation (activate) of APCs in T cells

9) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.23 Pain Relevance 0.03

In contrast, CD80 and CD86 are inducible on DCs and other APCs upon stimulation.

Positive_regulation (inducible) of APCs in CD86

10) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.11 Pain Relevance 0.12

To derive average connection strength per neuron (qcon), the number of excited neurons needs to be estimated, based on the excitability (SAP), neuron density (?

Positive_regulation (estimated) of SAP in neuron

11) Confidence 0.07 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.15

include a number of acute phase genes such as fibrinogen, serum amyloid P-component, lipocalin 2, metallothioneins, and serum amyloid A2, which were shown to be suppressed by the PPAR?

Positive_regulation (serum) of amyloid P-component associated with alzheimer's dementia

12) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.42 Pain Relevance 0.16

Many cytokines can be produced by activated APCs, and these can either be pro- or anti-inflammatory [33, 34, 69].

Positive_regulation (activated) of APCs associated with inflammation and cytokine

13) Confidence 0.04 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.41 Pain Relevance 0.19

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