INT181826

Context Info Confidence 0.35 First Reported 2005 Last Reported 2011 Negated 0 Speculated 3 Reported most in Body Documents 4 Total Number 6 Disease Relevance 4.43 Pain Relevance 0.20

cytosol (Baat) peroxisome (Baat) transferase activity, transferring acyl groups (Baat) lipid metabolic process (Baat) cytoplasm (Baat)

Anatomy Link Frequency liver 2 fat 1 Baat (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 34 93.60 agonist 12 87.92 Glutamate 4 34.92 anesthesia 6 25.52 Eae 11 5.00 cerebral cortex 7 5.00 Central nervous system 5 5.00 Inflammation 5 5.00 medulla 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Obesity 378 100.00 Impaired Glucose Tolerance 25 94.24 Body Weight 78 90.16 Targeted Disruption 45 90.08 Diabetes Mellitus 18 74.88 Hyperlipidemia 4 74.32 Disease 3 58.40 Gallstones 2 58.08 Liver Disease 2 55.36 Weight Gain 6 50.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mRNA of PEPCK, G-6-Pase and UCP-2 in liver, and mRNA of UCP-1 in BAT were analyzed by real time PCR and normalized to a housekeeping gene (36B4) (Light Cycler 480 SYBR Green, Roche Diagnostics, Indianapolis, IN).

Spec (analyzed) Transcription (analyzed) of BAT in liver

1) Confidence 0.35 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.07 Pain Relevance 0.04

The mRNA of PEPCK, G-6-Pase and UCP-2 in liver, and mRNA of UCP-1 in BAT were analyzed by real time PCR and normalized to a housekeeping gene (36B4) (Light Cycler 480 SYBR Green, Roche Diagnostics, Indianapolis, IN).

Spec (analyzed) Transcription (mRNA) of BAT in liver

2) Confidence 0.35 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.07 Pain Relevance 0.04

The mRNA and protein expression levels of molecules involved in the regulation of thermogenesis and mitochondrial function were analyzed in BAT of the experimental animals.

Spec (analyzed) Transcription (analyzed) of BAT associated with obesity

3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.57 Pain Relevance 0

Thus the second aim of the present study was to investigate the effect of BOF and DAI on the mRNA expression of UCP1 and UCP2 in the BAT and WAT in high-fat diet-fed mice.

Transcription (expression) of BAT in fat associated with obesity

4) Confidence 0.29 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.41 Pain Relevance 0.07

There were no significant differences in UCP2 mRNA expression in BAT or WAT among the four groups (Fig. 4).

Transcription (expression) of BAT associated with obesity

5) Confidence 0.29 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.01 Pain Relevance 0.05

activates the transcription of mitochondrial uncoupling protein-1 (UCP-1) in BAT through interactions with the nuclear hormone receptors PPAR?

Transcription (transcription) of BAT associated with obesity

6) Confidence 0.25 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.31 Pain Relevance 0

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