INT181879

From wiki-pain
Revision as of 19:35, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.18
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
plasma 2
monocytes 1
embryonic stem cells 1
Apoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 90 98.72 Very High Very High Very High
Inflammation 66 91.08 High High
tolerance 2 87.96 High High
cytokine 21 87.32 High High
ischemia 5 86.48 High High
agonist 42 68.60 Quite High
imagery 8 66.60 Quite High
chemokine 4 53.92 Quite High
abdominal pain 1 32.56 Quite Low
headache 1 31.92 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 614 100.00 Very High Very High Very High
Repression 4 100.00 Very High Very High Very High
Rheumatoid Arthritis 93 98.72 Very High Very High Very High
Hypertriglyceridemia 2 98.08 Very High Very High Very High
Coronary Heart Disease 66 97.72 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

12 97.28 Very High Very High Very High
Atherosclerosis 107 96.60 Very High Very High Very High
Disease 57 91.56 High High
INFLAMMATION 73 91.08 High High
Atherosclerotic Plaque 6 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, active juvenile RA was associated with reduced HDL blood levels and a significant decrease in apoA-I concentration in plasma [14].
Negative_regulation (decrease) of apoA-I in plasma associated with rheumatoid arthritis and disorder of lipid metabolism
1) Confidence 0.55 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.22 Pain Relevance 0.39
To overcome apoA-I inhibition, A-SAA would be expected to localize in the same area.
Negative_regulation (inhibition) of apoA-I
2) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 0.54 Pain Relevance 0.17
We recently identified apolipoprotein A-I (apoA-I) as a specific inhibitor of contact-mediated activation of monocytes [5].
Negative_regulation (inhibitor) of apoA-I in monocytes associated with disorder of lipid metabolism
3) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.09 Pain Relevance 0.37
ABCA1-deficient mice generated by targeted gene ablation in DBA-1J embryonic stem cells demonstrated a 99.5% and 99.8% reduction in serum HDL-C and Apo AI levels, respectively.
Negative_regulation (reduction) of Apo AI in embryonic stem cells associated with disorder of lipid metabolism
4) Confidence 0.19 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.51 Pain Relevance 0
Clinical observations of premature CHD in patients with inherited disorders of metabolism resulting in low circulating HDL-C levels, such as homozygous Apo AI/CIII deficiency and hypoalphaproteinemia support the association between low serum HDL-C levels and atherosclerosis (Forte TM 1984).
Negative_regulation (deficiency) of Apo AI associated with atherosclerosis, coronary heart disease and disorder of lipid metabolism
5) Confidence 0.19 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.48 Pain Relevance 0
Lipoprotein metabolism

Staggerer mice display lowered plasma HDL cholesterol levels associated with decreased plasma apoA-I and apoA-II concentration.

Negative_regulation (decreased) of apoA-I in plasma associated with disorder of lipid metabolism
6) Confidence 0.16 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.72 Pain Relevance 0.07
case of rat, this induction leads to the repression of the ApoA-I gene
Negative_regulation (repression) of ApoA-I gene associated with repression
7) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.25 Pain Relevance 0.03
Dyslipidemia was present with elevated triglycerides (3.7–8.5 mmol/l), an abnormal cholesterol profile (HDL 0.4–0.7 mmol/l, LDL 2.1–2.3 mmol/l) and reduced apolipoprotein A1 (0.53–0.81 g/l).
Negative_regulation (reduced) of apolipoprotein A1 associated with hypertriglyceridemia and disorder of lipid metabolism
8) Confidence 0.06 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 1.28 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox