INT181918

From wiki-pain
Revision as of 05:26, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.62
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD3) nucleoplasm (SMAD3) transport (SMAD3)
plasma membrane (SMAD3) nucleus (SMAD3) intracellular (SMAD3)
SMAD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 68 91.00 High High
cytokine 9 90.40 High High
Inflammation 50 73.44 Quite High
Nerve growth factor 24 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 20 5.00 Very Low Very Low Very Low
corticosteroid 16 5.00 Very Low Very Low Very Low
qutenza 16 5.00 Very Low Very Low Very Low
metalloproteinase 15 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cough 364 96.92 Very High Very High Very High
Hypoxia 59 93.60 High High
Rheumatoid Arthritis 68 91.00 High High
Synovitis 17 85.44 High High
Reprotox - General 1 58 78.08 Quite High
INFLAMMATION 53 73.44 Quite High
Cancer 123 50.00 Quite Low
Metastasis 43 50.00 Quite Low
Airway Remodeling 36 44.56 Quite Low
Adhesions 39 43.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is due to the fact that p38 MAPK, which is downstream of MEK4, activates Smad3 through signaling crosstalk [156].
Positive_regulation (activates) of Smad3
1) Confidence 0.35 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.46 Pain Relevance 0
and SMAD3, the latter being the mediator of TGF-?
Positive_regulation (mediator) of SMAD3
2) Confidence 0.18 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.15 Pain Relevance 0.31
Smad2/3 activation in bronchial biopsies
Positive_regulation (activation) of Smad2/3
3) Confidence 0.02 Published 2009 Journal Respir Res Section Body Doc Link PMC2688489 Disease Relevance 0.44 Pain Relevance 0
The level of Smad2/3 activation expressed as % of nuclear staining cells was higher in ASM cells of chronic cough patients compared with normal controls (p < 0.05) (Figure 5A &5B).
Positive_regulation (activation) of Smad2/3 associated with cough
4) Confidence 0.02 Published 2009 Journal Respir Res Section Body Doc Link PMC2688489 Disease Relevance 0.45 Pain Relevance 0
Smad2/3 activation was detected using the rabbit polyclonal antibody for Smad2/3 (1:50, Upstate 07–408, Watford, UK) for 1 hour at room temperature.
Positive_regulation (activation) of Smad2/3
5) Confidence 0.02 Published 2009 Journal Respir Res Section Body Doc Link PMC2688489 Disease Relevance 0.05 Pain Relevance 0
Smad2/3 activation was detected using the rabbit polyclonal antibody for Smad2/3 (1:50, Upstate 07–408, Watford, UK) for 1 hour at room temperature.
Positive_regulation (activation) of Smad2/3
6) Confidence 0.02 Published 2009 Journal Respir Res Section Body Doc Link PMC2688489 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox