INT181920

Context Info Confidence 0.50 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.54 Pain Relevance 0.18

nuclear chromosome (MSH3) nucleus (MSH3) enzyme binding (MSH3)

MSH3 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 68 89.32 Inflammatory response 1 49.08 Arthritis 15 41.68 Inflammation 22 41.28 metalloproteinase 2 17.48 cytokine 8 5.00 Osteoarthritis 3 5.00 Pain 1 5.00 analgesia 1 5.00 pain pelvic 1 5.00

Disease Link Frequency Relevance Heat Microsatellite Instability 49 99.96 Stress 19 99.68 Endometrial Cancer 153 99.44 Cancer 106 90.24 Rheumatoid Arthritis 68 89.32 Carcinoma 61 65.52 Colon Cancer 8 65.52 Hyperplasia 21 63.92 INFLAMMATION 17 48.72 Arthritis 13 41.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RII), BAX, insulin-like growth factor II receptor (IGFIIR), MSH3, MSH6, caspase-5, and PTEN may promote MSI-positive endometrial carcinoma [8, 9].

Gene_expression (promote) of MSH3 associated with microsatellite instability and endometrial cancer

1) Confidence 0.50 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.70 Pain Relevance 0

complex that is important for repair of the single base mismatches that are characteristic of oxidative stress, and increased expression of hMSH3, a component of MutS?

Gene_expression (expression) of hMSH3 associated with stress

2) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.84 Pain Relevance 0.18

General Comments

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