INT181967

Context Info Confidence 0.09 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.04

peptidase activity (Gzmb) cytoplasm (Gzmb)

Gzmb (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 45 82.08 cytokine 3 5.00 Inflammation 3 5.00 methotrexate 2 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 45 82.08 Macrophage Activation Syndrome 29 75.88 Chronic Myeloid Leukemia 1 73.68 Hemophagocytic Lymphohistiocytosis 22 58.08 Disease 9 30.08 Systemic Lupus Erythematosus 2 21.96 Rheumatic Diseases 5 19.76 Congenital Anomalies 6 5.00 INFLAMMATION 4 5.00 Syndrome 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In our study both patient groups had granzyme B expression patterns indistinguishable from those seen in healthy controls, suggesting that the observed NK dysfunction is not likely to be related to abnormal granzyme B expression.

Regulation (had) of granzyme B

1) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.35 Pain Relevance 0.04

General Comments

This test has worked.