INT181969

Context Info Confidence 0.23 First Reported 2005 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 3.62 Pain Relevance 0.85

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) transmembrane transport (Prf1)

Anatomy Link Frequency T cells 6 NK cell 4 pore 2 Prf1 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 135 100.00 Central nervous system 56 87.88 nMDA receptor 10 77.24 long-term potentiation 11 70.32 Calcium channel 8 61.68 imagery 12 61.28 corticosteroid 98 53.12 Inflammation 13 46.68 dexamethasone 3 43.24 cytokine 22 30.64

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 135 100.00 Hemophagocytic Lymphohistiocytosis 66 98.92 Macrophage Activation Syndrome 87 96.84 Disease 34 86.24 Syndrome 16 80.36 Systemic Lupus Erythematosus 6 78.12 Rheumatic Diseases 15 75.92 Sprains And Strains 7 73.84 Immunization 7 68.92 Death 8 56.24

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In light of the discrepancy between past and present findings, we further sought to define the importance of perforin expression in promoting vascular permeability and functional impairment by crossing mice heterozygous for perforin (F1) with C57BL/6 Prf1?

Regulation (importance) of Gene_expression (expression) of perforin

1) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.11

Although no overall correlation between perforin expression and NK cell cytolytic activty was noted in our study, we still cannot exclude the possibility that, at least in some patients, reduced perforin expression might have functional significance.

Neg (no) Regulation (correlation) of Gene_expression (expression) of perforin in NK cell

2) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.82 Pain Relevance 0.11

+), and CD8+ T cells were also assessed for perforin and granzyme B expression by flow cytometry.

Regulation (assessed) of Gene_expression (expression) of perforin in T cells

3) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.40 Pain Relevance 0.31

However, the examination of the individual patterns of perforin staining revealed a small subgroup of JRA patients with a very low perforin content in NK cells.

Regulation (subgroup) of Gene_expression (content) of perforin in NK cells associated with rheumatoid arthritis

4) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.16 Pain Relevance 0.12

CD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.

Regulation (characterized) of Gene_expression (expression) of perforin in T cells

5) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0

The principle of the technique is based on stimulation of perforin expression by CD8+ T cells in presence of BLV proteins from a lysate of FLK-BLV cells.

Regulation (stimulation) of Gene_expression (expression) of perforin in T cells

6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736388 Disease Relevance 0.11 Pain Relevance 0

On the other hand, Chameau et al. [105] found by quantitative PCR that corticosterone did not change the mRNA expression of the pore-forming Cav1 subunit of the L-type Ca2+ channel, and ruled out transcriptional mechanisms in the effects they observed.

Neg (not) Regulation (change) of Gene_expression (expression) of pore-forming Cav1 subunit in pore

7) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.19

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