INT181972

Context Info Confidence 0.16 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.81 Pain Relevance 0.36

peptidase activity (Gzmb) cytoplasm (Gzmb)

Anatomy Link Frequency T cells 4 Gzmb (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 90 91.92 cytokine 17 31.60 Inflammation 6 5.00 methotrexate 4 5.00 tolerance 2 5.00 cINOD 2 5.00 anesthesia 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 90 91.92 Disease 18 83.52 Syndrome 6 80.36 Macrophage Activation Syndrome 58 75.88 Hemophagocytic Lymphohistiocytosis 44 74.56 Chronic Myeloid Leukemia 2 74.56 Immunization 7 68.92 Rheumatic Diseases 10 64.36 Congenital Anomalies 12 25.84 Systemic Lupus Erythematosus 4 21.96

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.

Regulation (characterized) of Gene_expression (expression) of granzyme B in T cells

1) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0

+), and CD8+ T cells were also assessed for perforin and granzyme B expression by flow cytometry.

Regulation (assessed) of Gene_expression (expression) of granzyme B in T cells

2) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.40 Pain Relevance 0.31

In our study both patient groups had granzyme B expression patterns indistinguishable from those seen in healthy controls, suggesting that the observed NK dysfunction is not likely to be related to abnormal granzyme B expression.

Regulation (had) of Gene_expression (expression) of granzyme B

3) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.35 Pain Relevance 0.04

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