INT181974

Context Info Confidence 0.01 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.28 Pain Relevance 0.14

cell proliferation (MAS1) plasma membrane (MAS1) signal transducer activity (MAS1)

MAS1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 45 87.44 Inflammation 3 58.84 cINOD 1 12.16 cytokine 3 5.00 methotrexate 2 5.00

Disease Link Frequency Relevance Heat Macrophage Activation Syndrome 29 100.00 Disease 9 99.20 Systemic Lupus Erythematosus 2 90.28 Rheumatic Diseases 5 88.08 Rheumatoid Arthritis 45 87.44 Hemophagocytic Lymphohistiocytosis 22 67.20 Congenital Anomalies 6 66.40 INFLAMMATION 4 58.84 Syndrome 3 5.00 Infection 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Other groups have noted low levels of perforin expression in cytotoxic cells from patients with sJRA in comparison with other clinical forms of the disease, suggesting that this feature might be responsible for the increased incidence of MAS [26,27].

Spec (might) Positive_regulation (responsible) of Positive_regulation (increased) of MAS associated with macrophage activation syndrome and disease

1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.28 Pain Relevance 0.14

General Comments

This test has worked.