INT181976

Context Info Confidence 0.00 First Reported 2005 Last Reported 2005 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.64 Pain Relevance 0.26

extracellular space (TNF, Gpi1) extracellular region (TNF, Gpi1) plasma membrane (TNF, Gpi1) isomerase activity (Gpi1) intracellular (TNF) carbohydrate metabolic process (Gpi1)

TNF (Homo sapiens) Gpi1 (Mus musculus)

Pain Link Frequency Relevance Heat methotrexate 2 100.00 rheumatoid arthritis 45 90.16 cytokine 3 5.00 Inflammation 3 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 45 90.16 Necrosis 2 81.28 Cancer 2 80.92 Hemophagocytic Lymphohistiocytosis 22 74.48 Macrophage Activation Syndrome 29 74.16 Disease 9 5.00 Congenital Anomalies 6 5.00 Rheumatic Diseases 5 5.00 INFLAMMATION 4 5.00 Syndrome 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, logistic regression analysis showed no statistically significant differences in NK function between patients with or without immunosuppressive treatment (independent variables: prednisone, methotrexate, and TNF-blocking agents; dependent variable NK cytolytic activity below 2SD of control samples, ?

TNF Neg (no) Regulation (differences) of Transcription (activity) of NK associated with methotrexate

1) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.64 Pain Relevance 0.26

General Comments

This test has worked.