INT182024

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.58
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Il6) extracellular region (TNF, Il6) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
plasma 2
TNF (Homo sapiens)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 99 99.68 Very High Very High Very High
Infliximab 96 97.80 Very High Very High Very High
cytokine 9 76.32 Quite High
Inflammation 6 65.88 Quite High
methotrexate 3 50.40 Quite High
Pain 3 40.80 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 99 99.68 Very High Very High Very High
Necrosis 12 96.32 Very High Very High Very High
Cancer 12 95.96 Very High Very High Very High
Disease 15 78.96 Quite High
INFLAMMATION 6 65.88 Quite High
Synovitis 3 64.44 Quite High
Chronic Disease 3 41.56 Quite Low
Pain 3 40.80 Quite Low
Frailty 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All plasma samples from these patients inhibited the IL-6 production usually induced by TNF-?.
TNF Positive_regulation (induced) of Gene_expression (production) of IL-6 in plasma
1) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.24 Pain Relevance 0.24
Therefore, a bioassay was developed using the properties of synoviocytes to produce IL-6 and osteoprotegerin (OPG) in response to TNF-?
TNF Positive_regulation (response) of Gene_expression (produce) of IL-6
2) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.55 Pain Relevance 0.36
The bioassay is based on the induction of IL-6 and osteoprotegerin (OPG) production by synoviocytes in response to TNF-?.
TNF Positive_regulation (induction) of Gene_expression (production) of IL-6
3) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064892 Disease Relevance 0.80 Pain Relevance 0.34

General Comments

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