INT182036

Context Info Confidence 0.13 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.74 Pain Relevance 0.67

plasma membrane (Sh2b2) cytoplasm (Sh2b2) signal transducer activity (Sh2b2)

Anatomy Link Frequency SH2 2 T cells 1 Sh2b2 (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 102 96.60 cytokine 80 95.96 Inflammation 64 95.60 rheumatoid arthritis 52 95.56 withdrawal 10 5.00 Spontaneous pain 10 5.00 Inflammatory response 10 5.00 Pain 8 5.00 IPN 6 5.00 allodynia 4 5.00

Disease Link Frequency Relevance Heat Arthritis 120 96.60 INFLAMMATION 74 95.60 Rheumatoid Arthritis 52 95.56 Leukemia 2 84.48 Necrosis 2 82.76 Cancer 2 82.40 Autoimmune Disease 11 66.56 Diabetes Mellitus 3 64.24 Targeted Disruption 18 50.00 Synovitis 1 45.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another negative regulator of hematopoietic cell development and function is SHP-1 (SRC homology 2 (SH2)-containing tyrosine phosphatase 1), that is mainly expressed in hematopoietic and lymphoid cells [8].

Gene_expression (containing) of SRC homology 2 in SH2

1) Confidence 0.13 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.36 Pain Relevance 0.13

Another negative regulator of hematopoietic cell development and function is SHP-1 (SRC homology 2 (SH2)-containing tyrosine phosphatase 1), that is mainly expressed in hematopoietic and lymphoid cells [8].

Gene_expression (expressed) of SRC homology 2 in SH2

2) Confidence 0.13 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.37 Pain Relevance 0.13

Second, a spontaneous point mutation in the gene encoding an Src homology 2 (SH2) domain of ZAP-70, a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in mice that resembles human RA in many respects [25].

Gene_expression (domain) of Src homology 2 in T cells associated with rheumatoid arthritis and arthritis

3) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.00 Pain Relevance 0.42

General Comments

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