INT182233

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.55
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR4) signal transducer activity (CCR4)
Anatomy Link Frequency
T cells 6
regulatory T cells 2
blood 1
leukocyte 1
Th1 cells 1
CCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 235 100.00 Very High Very High Very High
Inflammation 141 100.00 Very High Very High Very High
rheumatoid arthritis 173 99.84 Very High Very High Very High
Multiple sclerosis 77 98.56 Very High Very High Very High
Arthritis 50 96.64 Very High Very High Very High
methotrexate 6 81.88 Quite High
cytokine 86 79.36 Quite High
Inflammatory response 6 68.84 Quite High
psoriasis 7 55.68 Quite High
imagery 65 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 144 100.00 Very High Very High Very High
Rheumatoid Arthritis 177 99.84 Very High Very High Very High
Atherosclerotic Plaque 19 98.96 Very High Very High Very High
Multiple Sclerosis 90 98.56 Very High Very High Very High
Adhesions 98 98.16 Very High Very High Very High
Disease 101 97.48 Very High Very High Very High
Juvenile Chronic Polyarthritis 33 96.64 Very High Very High Very High
Hypersensitivity 6 95.92 Very High Very High Very High
Transverse Myelitis 27 94.72 High High
Atherosclerosis 102 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four chemokine receptors (CCR2b, CCR3, CCR4 and CCR6) could not be detected in RA samples or non-RA samples under our conditions.
Neg (not) Gene_expression (detected) of CCR4 associated with chemokine and rheumatoid arthritis
1) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.16 Pain Relevance 0.70
To confirm the expression of CCR4 on CSF T cells, RNA was isolated from CSF cells obtained from one patient with mononuclear pleiocytosis during the follow-up after postinfectious myelitis.
Gene_expression (expression) of CCR4 in T cells associated with transverse myelitis
2) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.33 Pain Relevance 0.16
The expression of CCR4 on CSF T cells was assessed using two different anti-CCR4 mAbs, clones 328B and 1G1.
Gene_expression (expression) of CCR4 in T cells
3) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.41 Pain Relevance 0.15
MS patients had slightly lower numbers of CCR4+/CD4+/CD45RO+ T cells in the CSF compared to paired blood samples (Table 1; p < 0.01), but CCR4 was still expressed by approximately 50% of all CD4+/CD45RO+ T cells in the CSF.
Gene_expression (expressed) of CCR4 in blood associated with multiple sclerosis
4) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.44 Pain Relevance 0.22
Since CCR4 has been associated with a Th2 phenotype [24,25], CSF levels of CCR4 were analyzed in six patients with multiple sclerosis (MS), a disease associated with Th1 responses in the CNS [26].
Spec (analyzed) Gene_expression (levels) of CCR4 associated with multiple sclerosis and disease
5) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.47 Pain Relevance 0.21
Even though percentages of CD4+ memory T cells expressing CCR4 and integrin ?
Gene_expression (expressing) of CCR4 in memory T cells
6) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.17 Pain Relevance 0.04
Next, we assessed CSF expression of CCR4, a chemokine receptor highly expressed by skin-homing T cells [5].
Gene_expression (expression) of CCR4 in T cells associated with chemokine
7) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.19 Pain Relevance 0.05
The expression of cutaneous leukocyte antigen (CLA) and CC-chemokine receptor 4 (CCR4; associated with skin-homing) as well as the expression of integrin ?
Gene_expression (expression) of CCR4 in leukocyte associated with chemokine
8) Confidence 0.40 Published 2006 Journal BMC Immunol Section Abstract Doc Link PMC1539023 Disease Relevance 0.36 Pain Relevance 0.19
Interestingly, T cells isolated from the small intestines and the skin are almost completely dichotomous in their expression of trafficking determinants; T cells from the skin express cutaneous leukocyte antigen (CLA) and CCR4, but lack integrin ?
Gene_expression (express) of CCR4 in T cells
9) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.14 Pain Relevance 0.04
It is well established that T cells isolated from the small intestines and the skin are nearly homogenously positive for mutually exclusive pairs of trafficking determinants; almost all T cells from the skin express CLA and CCR4, but lack integrin ?
Gene_expression (express) of CCR4 in T cells
10) Confidence 0.40 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.14 Pain Relevance 0.04
Human blood Th17 cells can be identified as a CD4+ T cell subset expressing both CCR4 and CCR6 [5] (Sallusto).
Gene_expression (expressing) of CCR4 in T cell
11) Confidence 0.30 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.29 Pain Relevance 0.17
These synovial CD4+CD25high regulatory T cells express increased levels of inflammation-related chemokine receptors, such as CCR4, CCR5, and CXCR4 [120].
Gene_expression (express) of CCR4 in regulatory T cells associated with chemokine and inflammation
12) Confidence 0.25 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.84 Pain Relevance 0.51
The majority of CD4+CD25high regulatory T cells express CCR4 and CCR8 [59], but other chemokine receptors and integrin molecules, such CD103, are also present.
Gene_expression (express) of CCR4 in regulatory T cells associated with chemokine
13) Confidence 0.19 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.29 Pain Relevance 0.21
Th1 cells preferentially express CCR5, CXCR3, and CXCR6, whereas Th2 cells preferentially express CCR4 and CCR8.
Gene_expression (express) of CCR4 in Th1 cells
14) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.41 Pain Relevance 0.31
CSF-1 induced expression of the proatherogenic chemokines CXCL10/IP-10, CCL2 and CCL7 but repressed expression of the antiatherogenic chemokine receptor CXCR4 [53].
Gene_expression (expression) of antiatherogenic chemokine receptor CXCR4 associated with chemokine
15) Confidence 0.01 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.90 Pain Relevance 0.30

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