INT182297

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.36
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14)
nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)
Anatomy Link Frequency
chondrocytes 2
adipocytes 2
nervous system 2
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 129 99.76 Very High Very High Very High
Osteoarthritis 138 98.80 Very High Very High Very High
Central nervous system 2 98.40 Very High Very High Very High
Inflammatory response 5 96.16 Very High Very High Very High
dexamethasone 43 90.80 High High
rheumatoid arthritis 73 80.56 Quite High
cytokine 44 79.00 Quite High
medulla 44 76.00 Quite High
Spinal cord 34 75.44 Quite High
Pain 19 56.56 Quite High
Disease Link Frequency Relevance Heat
Obesity 68 99.98 Very High Very High Very High
Apoptosis 22 99.80 Very High Very High Very High
INFLAMMATION 133 99.76 Very High Very High Very High
Injury 17 99.52 Very High Very High Very High
Osteoarthritis 140 98.80 Very High Very High Very High
Synovitis 4 97.92 Very High Very High Very High
Stress 84 96.16 Very High Very High Very High
Parkinson's Disease 1 88.08 High High
Arthritis 20 82.32 Quite High
Rheumatoid Arthritis 73 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced phosphorylation of p38-MAPK was inhibited in chondrocytes pre-treated with PE (Figure 4a).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of p38 in chondrocytes
1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.73 Pain Relevance 0.37
Figure 2 confirms that the action of LPS on mature adipocytes results in p38 protein phosphorylation with a peak obtained 5 minutes after stimulation.
Positive_regulation (results) of Phosphorylation (phosphorylation) of p38 in adipocytes associated with obesity
2) Confidence 0.31 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.10 Pain Relevance 0
ET-1 at 10 nM induced p38, Akt, p44/42, and SAP/JNK phosphorylation in a time-ordered manner.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of p38
3) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.05 Pain Relevance 0
for 30 min significantly increased the phosphorylation state of JNK and p38 MAP kinases (Figure 6).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38
4) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.08 Pain Relevance 0.57
To investigate the involvement of MAP kinase pathway in the inhibitory effect by melttin and bee venom on NO and PGE2 production, the activation of MAP kinase (phosphorylation of ERK, JNK and p38) induced by LPS and SNP was evaluated in both Raw 264.7 cells as well as synoviocytes.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of p38
5) Confidence 0.08 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.08 Pain Relevance 0.04
Inflammatory signalling resulting in p38 phosphorylation has been identified as an important determinant of synovitis severity [49].
Positive_regulation (resulting) of Phosphorylation (phosphorylation) of p38 associated with inflammation and synovitis
6) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.97 Pain Relevance 0.37
Stretch injury has also been shown to induce phosphorylation of p38MAP kinase and apoptosis in vascular, heart and lung cells.[105] Clearly, the importance of biomechanical stresses upon the nervous system warrants closer attention.


Positive_regulation (induce) of Phosphorylation (phosphorylation) of p38MAP kinase in nervous system associated with stress, injury and apoptosis
7) Confidence 0.01 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC2940090 Disease Relevance 1.34 Pain Relevance 0.18

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